Fractal stochastic modeling of spiking activity in suprachiasmatic nucleus neurons

Sung Il Kim, Jaeseung Jeong, Yongho Kwak, Yang In Kim, Seung Hun Jung, Kyoung Jin Lee

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Individual neurons in the suprachiasmatic nucleus (SCN), the master biological clock in mammals, autonomously produce highly complex patterns of spikes. We have shown that most (∼90%) SCN neurons exhibit truly stochastic interspike interval (ISI) patterns. The aim of this study was to understand the stochastic nature of the firing patterns in SCN neurons by analyzing the ISI sequences of 150 SCN neurons in hypothalamic slices. Fractal analysis, using the periodogram, Fano factor, and Allan factor, revealed the presence of a 1/f-type power-law (fractal) behavior in the ISI sequences. This fractal nature was persistent after the application of the GABAA receptor antagonist bicuculline, suggesting that the fractal stochastic activity is an intrinsic property of individual SCN neurons. Based on these physiological findings, we developed a computational model for the stochastic SCN neurons to find that their stochastic spiking activity was best described by a gamma point process whose mean firing rate was modulated by a fractal binomial noise. Taken together, we suggest that SCN neurons generate temporal spiking patterns using the fractal stochastic point process.

Original languageEnglish
Pages (from-to)39-51
Number of pages13
JournalJournal of Computational Neuroscience
Volume19
Issue number1
DOIs
Publication statusPublished - 2005 Aug 1

Fingerprint

Fractals
Suprachiasmatic Nucleus
Neurons
Stochastic Processes
Biological Clocks
GABA-A Receptor Antagonists
Bicuculline
Noise
Mammals

Keywords

  • Fractal
  • Gamma point processes
  • Interspike intervals
  • Long-term correlations
  • Stochastic
  • Suprachiasmatic nucleus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Fractal stochastic modeling of spiking activity in suprachiasmatic nucleus neurons. / Kim, Sung Il; Jeong, Jaeseung; Kwak, Yongho; Kim, Yang In; Jung, Seung Hun; Lee, Kyoung Jin.

In: Journal of Computational Neuroscience, Vol. 19, No. 1, 01.08.2005, p. 39-51.

Research output: Contribution to journalArticle

Kim, Sung Il ; Jeong, Jaeseung ; Kwak, Yongho ; Kim, Yang In ; Jung, Seung Hun ; Lee, Kyoung Jin. / Fractal stochastic modeling of spiking activity in suprachiasmatic nucleus neurons. In: Journal of Computational Neuroscience. 2005 ; Vol. 19, No. 1. pp. 39-51.
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