Free fatty acid is associated with thrombogenicity in cardioembolic stroke

Woo Keun Seo, Jin-Man Jung, Ji Hyun Kim, Seong Beom Koh, Oh Young Bang, Kyungmi Oh

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Recently, the role of free fatty acids (FFAs) in thromboembolism has re-emerged in the context of cardioembolic stroke. Therefore, we attempted to determine the role of FFAs in embolic risk in various potential sources of cardioembolism (PSCE). We hypothesized that if elevated FFA levels in stroke patients are associated with thrombogenesis, then patients with a well-known high risk of embolic sources would have high FFA levels. Methods: Data collected from 2 hospital-based stroke registries were analyzed to investigate the association between FFA and PSCE. Results: A total of 2,770 acute stroke patients, including 539 with cardioembolic stroke, were selected for analysis. FFA was an independent predictor for cardioembolism (OR 2.755, 95% CI 2.221-3.417, p < 0.001). Among the PSCE, FFA levels were significantly associated with high risk of atrial fibrillation (AF), valvular heart disease, congestive heart failure with low ejection fraction, left atrial thrombus, left ventricular thrombus, left atrial smoke, and ventricular wall motion abnormality. FFA levels increased with the number of PSCE per patient without interaction with the presence of AF. Conclusions: Among acute stroke patients, FFA levels increased in groups with higher risk of cardioembolic stroke irrespective of the presence of AF. These results suggest that enhanced thrombogenicity could be the main mechanism to explain the elevated FFA levels in patients with cardioembolic stroke.

Original languageEnglish
Pages (from-to)160-168
Number of pages9
JournalCerebrovascular Diseases
Volume44
Issue number3-4
DOIs
Publication statusPublished - 2017 Oct 1

Fingerprint

Nonesterified Fatty Acids
Stroke
Atrial Fibrillation
Thrombosis
Heart Valve Diseases
Thromboembolism
Smoke
Registries
Heart Failure

Keywords

  • Biomarker
  • Cardioembolism
  • Free fatty acid
  • Stroke
  • Thrombosis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Free fatty acid is associated with thrombogenicity in cardioembolic stroke. / Seo, Woo Keun; Jung, Jin-Man; Kim, Ji Hyun; Koh, Seong Beom; Bang, Oh Young; Oh, Kyungmi.

In: Cerebrovascular Diseases, Vol. 44, No. 3-4, 01.10.2017, p. 160-168.

Research output: Contribution to journalArticle

@article{44d984f5abcc4404984ca632e9d2c767,
title = "Free fatty acid is associated with thrombogenicity in cardioembolic stroke",
abstract = "Background: Recently, the role of free fatty acids (FFAs) in thromboembolism has re-emerged in the context of cardioembolic stroke. Therefore, we attempted to determine the role of FFAs in embolic risk in various potential sources of cardioembolism (PSCE). We hypothesized that if elevated FFA levels in stroke patients are associated with thrombogenesis, then patients with a well-known high risk of embolic sources would have high FFA levels. Methods: Data collected from 2 hospital-based stroke registries were analyzed to investigate the association between FFA and PSCE. Results: A total of 2,770 acute stroke patients, including 539 with cardioembolic stroke, were selected for analysis. FFA was an independent predictor for cardioembolism (OR 2.755, 95{\%} CI 2.221-3.417, p < 0.001). Among the PSCE, FFA levels were significantly associated with high risk of atrial fibrillation (AF), valvular heart disease, congestive heart failure with low ejection fraction, left atrial thrombus, left ventricular thrombus, left atrial smoke, and ventricular wall motion abnormality. FFA levels increased with the number of PSCE per patient without interaction with the presence of AF. Conclusions: Among acute stroke patients, FFA levels increased in groups with higher risk of cardioembolic stroke irrespective of the presence of AF. These results suggest that enhanced thrombogenicity could be the main mechanism to explain the elevated FFA levels in patients with cardioembolic stroke.",
keywords = "Biomarker, Cardioembolism, Free fatty acid, Stroke, Thrombosis",
author = "Seo, {Woo Keun} and Jin-Man Jung and Kim, {Ji Hyun} and Koh, {Seong Beom} and Bang, {Oh Young} and Kyungmi Oh",
year = "2017",
month = "10",
day = "1",
doi = "10.1159/000478895",
language = "English",
volume = "44",
pages = "160--168",
journal = "Cerebrovascular Diseases",
issn = "1015-9770",
publisher = "S. Karger AG",
number = "3-4",

}

TY - JOUR

T1 - Free fatty acid is associated with thrombogenicity in cardioembolic stroke

AU - Seo, Woo Keun

AU - Jung, Jin-Man

AU - Kim, Ji Hyun

AU - Koh, Seong Beom

AU - Bang, Oh Young

AU - Oh, Kyungmi

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Background: Recently, the role of free fatty acids (FFAs) in thromboembolism has re-emerged in the context of cardioembolic stroke. Therefore, we attempted to determine the role of FFAs in embolic risk in various potential sources of cardioembolism (PSCE). We hypothesized that if elevated FFA levels in stroke patients are associated with thrombogenesis, then patients with a well-known high risk of embolic sources would have high FFA levels. Methods: Data collected from 2 hospital-based stroke registries were analyzed to investigate the association between FFA and PSCE. Results: A total of 2,770 acute stroke patients, including 539 with cardioembolic stroke, were selected for analysis. FFA was an independent predictor for cardioembolism (OR 2.755, 95% CI 2.221-3.417, p < 0.001). Among the PSCE, FFA levels were significantly associated with high risk of atrial fibrillation (AF), valvular heart disease, congestive heart failure with low ejection fraction, left atrial thrombus, left ventricular thrombus, left atrial smoke, and ventricular wall motion abnormality. FFA levels increased with the number of PSCE per patient without interaction with the presence of AF. Conclusions: Among acute stroke patients, FFA levels increased in groups with higher risk of cardioembolic stroke irrespective of the presence of AF. These results suggest that enhanced thrombogenicity could be the main mechanism to explain the elevated FFA levels in patients with cardioembolic stroke.

AB - Background: Recently, the role of free fatty acids (FFAs) in thromboembolism has re-emerged in the context of cardioembolic stroke. Therefore, we attempted to determine the role of FFAs in embolic risk in various potential sources of cardioembolism (PSCE). We hypothesized that if elevated FFA levels in stroke patients are associated with thrombogenesis, then patients with a well-known high risk of embolic sources would have high FFA levels. Methods: Data collected from 2 hospital-based stroke registries were analyzed to investigate the association between FFA and PSCE. Results: A total of 2,770 acute stroke patients, including 539 with cardioembolic stroke, were selected for analysis. FFA was an independent predictor for cardioembolism (OR 2.755, 95% CI 2.221-3.417, p < 0.001). Among the PSCE, FFA levels were significantly associated with high risk of atrial fibrillation (AF), valvular heart disease, congestive heart failure with low ejection fraction, left atrial thrombus, left ventricular thrombus, left atrial smoke, and ventricular wall motion abnormality. FFA levels increased with the number of PSCE per patient without interaction with the presence of AF. Conclusions: Among acute stroke patients, FFA levels increased in groups with higher risk of cardioembolic stroke irrespective of the presence of AF. These results suggest that enhanced thrombogenicity could be the main mechanism to explain the elevated FFA levels in patients with cardioembolic stroke.

KW - Biomarker

KW - Cardioembolism

KW - Free fatty acid

KW - Stroke

KW - Thrombosis

UR - http://www.scopus.com/inward/record.url?scp=85025464361&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85025464361&partnerID=8YFLogxK

U2 - 10.1159/000478895

DO - 10.1159/000478895

M3 - Article

C2 - 28715812

AN - SCOPUS:85025464361

VL - 44

SP - 160

EP - 168

JO - Cerebrovascular Diseases

JF - Cerebrovascular Diseases

SN - 1015-9770

IS - 3-4

ER -