Frequency doubling of ultrashort laser pulses in biological tissues

Beop Min Kim, Jürgen Eichler, Luiz B. Da Silva

Research output: Contribution to journalArticle

49 Citations (Scopus)


Theoretical and experimental studies of second-harmonic generation (SHG) in biological tissues was performed by use of ultrashort laser pulses (<1 ps). A simplified one-dimensional model for the generation and the propagation of frequency-doubled light inside tissue was developed. This model was tested in vitro against measurements of pig and chicken tissue and human tooth. The experimental results indicate that the intensity of SHG varies significantly among tissue types and between test sites in individual tissue. Possibilities of using this nonlinear tissue property in imaging and diagnostics are discussed.

Original languageEnglish
Pages (from-to)7145-7150
Number of pages6
JournalApplied optics
Issue number34
Publication statusPublished - 1999 Dec 1

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Engineering (miscellaneous)
  • Electrical and Electronic Engineering

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