Frequency of cytochrome P450 2C9 mutant alleles in a Korean population

Young Ran Yoon, Ji Hong Shon, Moon Kyung Kim, Young Chai Lim, Hye Rang Lee, Ji-Young Park, In June Cha, Jae Gook Shin

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

Aims: To determine the frequencies of CYP2C9 variants in the Korean population and compare them with the frequencies in other ethnic populations. Methods: Genotyping of CYP2C9*2 and CYP2C9*3 allelic variants was carried out in 574 Korean subjects by PCR and restriction fragment length pattern analysis. Results: Thirteen of 574 subjects (2.3%) were heterozygous for CYP2C9*3 (Ile359Leu), but no subjects with a CYP2C9*2 allele or homozygous for CYP2C9*3 were identified. The allele frequency of CYP2C9*3 in Korean subjects (0.0113, 95% CI 0.0066-0.0193) was similar to that of other East Asian populations, but was considerably lower than that of Caucasian populations. Conclusions: CYP2C9*3 seems to be an allelic variant related to the functional polymorphism of CYP2C9, but this variant is rarely seen among Koreans compared with Caucasians. Routine genotyping of the CYP2C9*2 allele is considered to be unnecessary in Korean and East Asians, because this allele appears to be extremely rare or absent in these populations.

Original languageEnglish
Pages (from-to)277-280
Number of pages4
JournalBritish Journal of Clinical Pharmacology
Volume51
Issue number3
DOIs
Publication statusPublished - 2001 May 14
Externally publishedYes

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Cytochrome P-450 Enzyme System
Alleles
Population
Cytochrome P-450 CYP2C9
Gene Frequency
Polymerase Chain Reaction

Keywords

  • CYP2C9
  • Genotype
  • Korean

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Frequency of cytochrome P450 2C9 mutant alleles in a Korean population. / Yoon, Young Ran; Shon, Ji Hong; Kim, Moon Kyung; Lim, Young Chai; Lee, Hye Rang; Park, Ji-Young; Cha, In June; Shin, Jae Gook.

In: British Journal of Clinical Pharmacology, Vol. 51, No. 3, 14.05.2001, p. 277-280.

Research output: Contribution to journalArticle

Yoon, Young Ran ; Shon, Ji Hong ; Kim, Moon Kyung ; Lim, Young Chai ; Lee, Hye Rang ; Park, Ji-Young ; Cha, In June ; Shin, Jae Gook. / Frequency of cytochrome P450 2C9 mutant alleles in a Korean population. In: British Journal of Clinical Pharmacology. 2001 ; Vol. 51, No. 3. pp. 277-280.
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AU - Lim, Young Chai

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AU - Park, Ji-Young

AU - Cha, In June

AU - Shin, Jae Gook

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