Frequency of cytochrome P450 2C9 mutant alleles in a Korean population

Young Ran Yoon, Ji Hong Shon, Moon Kyung Kim, Young Chai Lim, Hye Rang Lee, Ji Young Park, In June Cha, Jae Gook Shin

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120 Citations (Scopus)

Abstract

Aims: To determine the frequencies of CYP2C9 variants in the Korean population and compare them with the frequencies in other ethnic populations. Methods: Genotyping of CYP2C9*2 and CYP2C9*3 allelic variants was carried out in 574 Korean subjects by PCR and restriction fragment length pattern analysis. Results: Thirteen of 574 subjects (2.3%) were heterozygous for CYP2C9*3 (Ile359Leu), but no subjects with a CYP2C9*2 allele or homozygous for CYP2C9*3 were identified. The allele frequency of CYP2C9*3 in Korean subjects (0.0113, 95% CI 0.0066-0.0193) was similar to that of other East Asian populations, but was considerably lower than that of Caucasian populations. Conclusions: CYP2C9*3 seems to be an allelic variant related to the functional polymorphism of CYP2C9, but this variant is rarely seen among Koreans compared with Caucasians. Routine genotyping of the CYP2C9*2 allele is considered to be unnecessary in Korean and East Asians, because this allele appears to be extremely rare or absent in these populations.

Original languageEnglish
Pages (from-to)277-280
Number of pages4
JournalBritish Journal of Clinical Pharmacology
Volume51
Issue number3
DOIs
Publication statusPublished - 2001

Keywords

  • CYP2C9
  • Genotype
  • Korean

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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    Yoon, Y. R., Shon, J. H., Kim, M. K., Lim, Y. C., Lee, H. R., Park, J. Y., Cha, I. J., & Shin, J. G. (2001). Frequency of cytochrome P450 2C9 mutant alleles in a Korean population. British Journal of Clinical Pharmacology, 51(3), 277-280. https://doi.org/10.1046/j.1365-2125.2001.00340.x