Friend or foe: Paradoxical roles of autophagy in gliomagenesis

Don Carlo Ramos Batara, Moon Chang Choi, Hyeon Uk Shin, Hyunggee Kim, Sung Hak Kim

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Glioblastoma multiforme (GBM) is the most common and aggressive type of primary brain tumor in adults, with a poor median survival of approximately 15 months after diagnosis. Despite several decades of intensive research on its cancer biology, treatment for GBM remains a challenge. Autophagy, a fundamental homeostatic mechanism, is responsible for degrading and recycling damaged or defective cellular components. It plays a paradoxical role in GBM by either promoting or suppressing tumor growth depending on the cellular context. A thorough understanding of autophagy’s pleiotropic roles is needed to develop potential therapeutic strategies for GBM. In this paper, we discussed molecular mechanisms and biphasic functions of autophagy in gliomagenesis. We also provided a summary of treatments for GBM, emphasizing the importance of autophagy as a promising molecular target for treating GBM.

Original languageEnglish
Article number1411
JournalCells
Volume10
Issue number6
DOIs
Publication statusPublished - 2021 Jun

Keywords

  • Autophagy
  • Glioblastoma multiforme
  • Treatment

ASJC Scopus subject areas

  • Medicine(all)

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