Function of Fimsbactin B as an Acinetobacter-Selective Antibiotic Delivery Vehicle

Do Young Kim, Hak Joong Kim

Research output: Contribution to journalArticlepeer-review

Abstract

The ability of fimsbactin B, a natural siderophore of Acinetobacter baumannii, to function as an antibiotic delivery vehicle was investigated by synthesizing three structurally diversified fimsbactin B-cefaclor conjugates. Their antimicrobial activities were Acinetobacter-selective and up to 128-fold more potent than that of cefaclor alone. This activity enhancement originated from the fimsbactin-B-dependent active uptake of cefaclor. Thus, fimsbactin-B-based antibiotic delivery can be an effective approach in combating antibiotic-resistant Acinetobacter infections.

Original languageEnglish
Pages (from-to)5256-5260
Number of pages5
JournalOrganic Letters
Volume23
Issue number13
DOIs
Publication statusPublished - 2021 Jul 2

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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