Functional and prognostic implications of the main pulmonary artery diameter to aorta diameter ratio from chest computed tomography in Korean COPD patients

Korean Obstructive Lung Disease Study Group

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: The ratio of the diameter of the main pulmonary artery (mPA) to the diameter of the aorta (Ao) on chest computed tomography is associated with diverse clinical conditions. Herein, we determined the functional and prognostic implications of the mPA/Ao ratio in Korean chronic obstructive pulmonary disease (COPD) patients. Methods: The study population comprised 226 chronic obstructive pulmonary disease patients from the Korean Obstructive Lung Disease cohort who underwent chest computed tomography. We analyzed the relationships between the clinical characteristics, including pulmonary function, echocardiography findings, St. George's Respiratory Questionnaire, 6-minute walking (6MW) distance, and exacerbation with the mPA, Ao, and mPA/Ao ratio. Results: The mean age was 65.8 years, and 219 (96.9%) patients were male. The mean FEV1% predicted and FEV1/FVC ratio were 61.2% and 47.3%, respectively. The mean mPA and Ao were 23.7 and 36.4 mm, respectively, and the mPA/Ao ratio was 0.66. The mPA/Ao ratio correlated negatively with the 6MW distance (G = -0.133, P = 0.025) and positively with the right ventricular pressure (G = 0.323, P = 0.001). After adjustment for potential confounders, the mPA/Ao ratio was significantly associated with 6MW distance (β = -107.7, P = 0.017). Moreover, an mPA/Ao ratio >0.8 was a significant predictor of exacerbation at the 1-year (odds ratio 2.12, 95% confidence interval 1.27-3.52) and 3-year follow-ups (odds ratio 2.04, 95% confidence interval 1.42-2.90). Conclusions: The mPA/Ao ratio is an independent predictor of exercise capacity and an mPA/Ao ratio >0.8 is a significant risk factor of COPD exacerbation.

Original languageEnglish
Article numbere0154584
JournalPLoS One
Volume11
Issue number5
DOIs
Publication statusPublished - 2016 May 1
Externally publishedYes

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Pulmonary diseases
pulmonary artery
chest
aorta
computed tomography
respiratory tract diseases
Chronic Obstructive Pulmonary Disease
Pulmonary Artery
Tomography
Aorta
Thorax
Echocardiography
walking
Walking
odds ratio
confidence interval
Odds Ratio
Confidence Intervals
Obstructive Lung Diseases
lung function

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Functional and prognostic implications of the main pulmonary artery diameter to aorta diameter ratio from chest computed tomography in Korean COPD patients. / Korean Obstructive Lung Disease Study Group.

In: PLoS One, Vol. 11, No. 5, e0154584, 01.05.2016.

Research output: Contribution to journalArticle

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title = "Functional and prognostic implications of the main pulmonary artery diameter to aorta diameter ratio from chest computed tomography in Korean COPD patients",
abstract = "Background: The ratio of the diameter of the main pulmonary artery (mPA) to the diameter of the aorta (Ao) on chest computed tomography is associated with diverse clinical conditions. Herein, we determined the functional and prognostic implications of the mPA/Ao ratio in Korean chronic obstructive pulmonary disease (COPD) patients. Methods: The study population comprised 226 chronic obstructive pulmonary disease patients from the Korean Obstructive Lung Disease cohort who underwent chest computed tomography. We analyzed the relationships between the clinical characteristics, including pulmonary function, echocardiography findings, St. George's Respiratory Questionnaire, 6-minute walking (6MW) distance, and exacerbation with the mPA, Ao, and mPA/Ao ratio. Results: The mean age was 65.8 years, and 219 (96.9{\%}) patients were male. The mean FEV1{\%} predicted and FEV1/FVC ratio were 61.2{\%} and 47.3{\%}, respectively. The mean mPA and Ao were 23.7 and 36.4 mm, respectively, and the mPA/Ao ratio was 0.66. The mPA/Ao ratio correlated negatively with the 6MW distance (G = -0.133, P = 0.025) and positively with the right ventricular pressure (G = 0.323, P = 0.001). After adjustment for potential confounders, the mPA/Ao ratio was significantly associated with 6MW distance (β = -107.7, P = 0.017). Moreover, an mPA/Ao ratio >0.8 was a significant predictor of exacerbation at the 1-year (odds ratio 2.12, 95{\%} confidence interval 1.27-3.52) and 3-year follow-ups (odds ratio 2.04, 95{\%} confidence interval 1.42-2.90). Conclusions: The mPA/Ao ratio is an independent predictor of exercise capacity and an mPA/Ao ratio >0.8 is a significant risk factor of COPD exacerbation.",
author = "{Korean Obstructive Lung Disease Study Group} and Chung, {Kyung Soo} and Kim, {Young Sam} and Kim, {Se Kyu} and Kim, {Ha Yan} and Lee, {Sang Min} and Seo, {Joon Beom} and Oh, {Yeon Mok} and Jung, {Ji Ye} and Lee, {Sang Do} and Lee, {Ji Hyun} and Kim, {Eun Kyung} and Kim, {Tae Hyung} and Shin, {Tae Rim} and Yoo, {Kwang Ha} and Sheen, {Seung Soo} and Lee, {Jin Hwa} and Lim, {Seong Yong} and Lee, {Sang Yeub} and Yoon, {Ho Il} and Park, {Yong Bum} and Hwang, {Yong Il} and Yoonki Hong and Ra, {Seung Won} and Lee, {Sei Won} and Lee, {Jae Seung} and Huh, {Jin Won} and Moon, {Ji Yong} and Park, {Hye Kyeong} and Park, {Hye Yun} and Kim, {Jin Woo} and Rhee, {Chin Kook} and Yoon, {Hyoung Kyu} and Kim, {Woo Jin} and Oh, {Yeon Mok}",
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T1 - Functional and prognostic implications of the main pulmonary artery diameter to aorta diameter ratio from chest computed tomography in Korean COPD patients

AU - Korean Obstructive Lung Disease Study Group

AU - Chung, Kyung Soo

AU - Kim, Young Sam

AU - Kim, Se Kyu

AU - Kim, Ha Yan

AU - Lee, Sang Min

AU - Seo, Joon Beom

AU - Oh, Yeon Mok

AU - Jung, Ji Ye

AU - Lee, Sang Do

AU - Lee, Ji Hyun

AU - Kim, Eun Kyung

AU - Kim, Tae Hyung

AU - Shin, Tae Rim

AU - Yoo, Kwang Ha

AU - Sheen, Seung Soo

AU - Lee, Jin Hwa

AU - Lim, Seong Yong

AU - Lee, Sang Yeub

AU - Yoon, Ho Il

AU - Park, Yong Bum

AU - Hwang, Yong Il

AU - Hong, Yoonki

AU - Ra, Seung Won

AU - Lee, Sei Won

AU - Lee, Jae Seung

AU - Huh, Jin Won

AU - Moon, Ji Yong

AU - Park, Hye Kyeong

AU - Park, Hye Yun

AU - Kim, Jin Woo

AU - Rhee, Chin Kook

AU - Yoon, Hyoung Kyu

AU - Kim, Woo Jin

AU - Oh, Yeon Mok

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Background: The ratio of the diameter of the main pulmonary artery (mPA) to the diameter of the aorta (Ao) on chest computed tomography is associated with diverse clinical conditions. Herein, we determined the functional and prognostic implications of the mPA/Ao ratio in Korean chronic obstructive pulmonary disease (COPD) patients. Methods: The study population comprised 226 chronic obstructive pulmonary disease patients from the Korean Obstructive Lung Disease cohort who underwent chest computed tomography. We analyzed the relationships between the clinical characteristics, including pulmonary function, echocardiography findings, St. George's Respiratory Questionnaire, 6-minute walking (6MW) distance, and exacerbation with the mPA, Ao, and mPA/Ao ratio. Results: The mean age was 65.8 years, and 219 (96.9%) patients were male. The mean FEV1% predicted and FEV1/FVC ratio were 61.2% and 47.3%, respectively. The mean mPA and Ao were 23.7 and 36.4 mm, respectively, and the mPA/Ao ratio was 0.66. The mPA/Ao ratio correlated negatively with the 6MW distance (G = -0.133, P = 0.025) and positively with the right ventricular pressure (G = 0.323, P = 0.001). After adjustment for potential confounders, the mPA/Ao ratio was significantly associated with 6MW distance (β = -107.7, P = 0.017). Moreover, an mPA/Ao ratio >0.8 was a significant predictor of exacerbation at the 1-year (odds ratio 2.12, 95% confidence interval 1.27-3.52) and 3-year follow-ups (odds ratio 2.04, 95% confidence interval 1.42-2.90). Conclusions: The mPA/Ao ratio is an independent predictor of exercise capacity and an mPA/Ao ratio >0.8 is a significant risk factor of COPD exacerbation.

AB - Background: The ratio of the diameter of the main pulmonary artery (mPA) to the diameter of the aorta (Ao) on chest computed tomography is associated with diverse clinical conditions. Herein, we determined the functional and prognostic implications of the mPA/Ao ratio in Korean chronic obstructive pulmonary disease (COPD) patients. Methods: The study population comprised 226 chronic obstructive pulmonary disease patients from the Korean Obstructive Lung Disease cohort who underwent chest computed tomography. We analyzed the relationships between the clinical characteristics, including pulmonary function, echocardiography findings, St. George's Respiratory Questionnaire, 6-minute walking (6MW) distance, and exacerbation with the mPA, Ao, and mPA/Ao ratio. Results: The mean age was 65.8 years, and 219 (96.9%) patients were male. The mean FEV1% predicted and FEV1/FVC ratio were 61.2% and 47.3%, respectively. The mean mPA and Ao were 23.7 and 36.4 mm, respectively, and the mPA/Ao ratio was 0.66. The mPA/Ao ratio correlated negatively with the 6MW distance (G = -0.133, P = 0.025) and positively with the right ventricular pressure (G = 0.323, P = 0.001). After adjustment for potential confounders, the mPA/Ao ratio was significantly associated with 6MW distance (β = -107.7, P = 0.017). Moreover, an mPA/Ao ratio >0.8 was a significant predictor of exacerbation at the 1-year (odds ratio 2.12, 95% confidence interval 1.27-3.52) and 3-year follow-ups (odds ratio 2.04, 95% confidence interval 1.42-2.90). Conclusions: The mPA/Ao ratio is an independent predictor of exercise capacity and an mPA/Ao ratio >0.8 is a significant risk factor of COPD exacerbation.

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DO - 10.1371/journal.pone.0154584

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VL - 11

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JF - PLoS One

SN - 1932-6203

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