Functional genomics of trypanosomatids

J. Choi, N. M. El-Sayed

Research output: Contribution to journalReview articlepeer-review

21 Citations (Scopus)

Abstract

The decoding of the Tritryp reference genomes nearly 7years ago provided a first peek into the biology of pathogenic trypanosomatids and a blueprint that has paved the way for genome-wide studies. Although 60-70% of the predicted protein coding genes in Trypanosoma brucei, Trypanosoma cruzi and Leishmania major remain unannotated, the functional genomics landscape is rapidly changing. Facilitated by the advent of next-generation sequencing technologies, improved structural and functional annotation and genes and their products are emerging. Information is also growing for the interactions between cellular components as transcriptomes, regulatory networks and metabolomes are characterized, ushering in a new era of systems biology. Simultaneously, the launch of comparative sequencing of multiple strains of kinetoplastids will finally lead to the investigation of a vast, yet to be explored, evolutionary and pathogenomic space.

Original languageEnglish
Pages (from-to)72-79
Number of pages8
JournalParasite Immunology
Volume34
Issue number2-3
DOIs
Publication statusPublished - 2012 Feb
Externally publishedYes

Keywords

  • Comparative
  • Genomics
  • Metabolome
  • Protein-protein interactions
  • Proteome
  • Transcriptome
  • Trypanosomatids

ASJC Scopus subject areas

  • Parasitology
  • Immunology

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