Functional magnetic resonance cholangiography with Gd-EOB-DTPA: A study in healthy volunteers

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Abstract

Purpose: To describe the patterns of bile distribution in the biliary tree, duodenum, jejunum, and stomach, and to determine the gallbladder ejection fraction (GBEF) by using functional magnetic resonance cholangiography (MRC) with gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid (Gd-EOB-DTPA) in healthy volunteers. Materials and Methods: Forty subjects were included in this study. After conventional MRC, pre-fatty meal MRC (PRFM) was obtained at 30, 40, 50, and 60. min after contrast agent injection. Then, post-fatty meal MRC (POFM) was obtained every 10. min for 1. h. We assessed the PRFM and POFM for opacification of contrast agent in the first- and second-order intrahepatic ducts (IHDs) and the common bile duct (CBD). Contrast agent opacification in the cystic duct was assessed, and the percentage volume of contrast agent filling in the gallbladder (GB) was calculated on PRFM. We calculated the GBEF and assessed the presence of contrast agent in the GB, duodenum, jejunum, and stomach. Results: Thirty-six (90%) subjects showed grade 3 CBD opacification (visible contrast and well-defined bile duct border) on 60-min PRFM. Thirty-four (85%) subjects showed grade 3 first-order IHD opacification on 60-min PRFM. All (100%) subjects showed cystic duct opacification of contrast agent, and the average percentage volume of contrast agent filling in the GB was 68.81%. ±. 16.84% on 60-min PRFM. The GBEF at 30-min POFM was 35.00%. ±. 18.26%. Ten (25%) subjects had no contrast agent in the stomach and small bowel on all PRFMs. Twelve (30%) subjects had contrast medium in the stomach on PRFM and/or POFM. Conclusions: Functional MRC with Gd-EOB-DTPA can allow determining the distribution of bile in the biliary tree and small intestine, as well as the GBEF.

Original languageEnglish
Pages (from-to)385-391
Number of pages7
JournalMagnetic Resonance Imaging
Volume32
Issue number4
DOIs
Publication statusPublished - 2014 Jan 1

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Rubiaceae
Cholangiography
Gadolinium
Magnetic resonance
Acetic acid
Acetic Acid
Meals
Healthy Volunteers
Ducts
Magnetic Resonance Spectroscopy
Contrast Media
Gallbladder
Stomach
Cystic Duct
Common Bile Duct
Biliary Tract
Jejunum
Duodenum
Bile
Contrast media

Keywords

  • Bile ducts
  • Contrast medium
  • Gastrointestinal tract
  • Gd-EOB-DTPA
  • Magnetic resonance

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Biomedical Engineering
  • Medicine(all)

Cite this

@article{89f7920f324f4744b89cf7e1994c6429,
title = "Functional magnetic resonance cholangiography with Gd-EOB-DTPA: A study in healthy volunteers",
abstract = "Purpose: To describe the patterns of bile distribution in the biliary tree, duodenum, jejunum, and stomach, and to determine the gallbladder ejection fraction (GBEF) by using functional magnetic resonance cholangiography (MRC) with gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid (Gd-EOB-DTPA) in healthy volunteers. Materials and Methods: Forty subjects were included in this study. After conventional MRC, pre-fatty meal MRC (PRFM) was obtained at 30, 40, 50, and 60. min after contrast agent injection. Then, post-fatty meal MRC (POFM) was obtained every 10. min for 1. h. We assessed the PRFM and POFM for opacification of contrast agent in the first- and second-order intrahepatic ducts (IHDs) and the common bile duct (CBD). Contrast agent opacification in the cystic duct was assessed, and the percentage volume of contrast agent filling in the gallbladder (GB) was calculated on PRFM. We calculated the GBEF and assessed the presence of contrast agent in the GB, duodenum, jejunum, and stomach. Results: Thirty-six (90{\%}) subjects showed grade 3 CBD opacification (visible contrast and well-defined bile duct border) on 60-min PRFM. Thirty-four (85{\%}) subjects showed grade 3 first-order IHD opacification on 60-min PRFM. All (100{\%}) subjects showed cystic duct opacification of contrast agent, and the average percentage volume of contrast agent filling in the GB was 68.81{\%}. ±. 16.84{\%} on 60-min PRFM. The GBEF at 30-min POFM was 35.00{\%}. ±. 18.26{\%}. Ten (25{\%}) subjects had no contrast agent in the stomach and small bowel on all PRFMs. Twelve (30{\%}) subjects had contrast medium in the stomach on PRFM and/or POFM. Conclusions: Functional MRC with Gd-EOB-DTPA can allow determining the distribution of bile in the biliary tree and small intestine, as well as the GBEF.",
keywords = "Bile ducts, Contrast medium, Gastrointestinal tract, Gd-EOB-DTPA, Magnetic resonance",
author = "Lee, {Seung Hwa} and Cha, {Sang Hoon} and Chung, {Hwan Hoon} and Kim, {Kee Hwan} and Yeom, {Suk Keu} and Seo, {Bo Kyoung} and Bo-Kyung Je and Kim, {Baek Hyun}",
year = "2014",
month = "1",
day = "1",
doi = "10.1016/j.mri.2014.01.003",
language = "English",
volume = "32",
pages = "385--391",
journal = "Magnetic Resonance Imaging",
issn = "0730-725X",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Functional magnetic resonance cholangiography with Gd-EOB-DTPA

T2 - A study in healthy volunteers

AU - Lee, Seung Hwa

AU - Cha, Sang Hoon

AU - Chung, Hwan Hoon

AU - Kim, Kee Hwan

AU - Yeom, Suk Keu

AU - Seo, Bo Kyoung

AU - Je, Bo-Kyung

AU - Kim, Baek Hyun

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Purpose: To describe the patterns of bile distribution in the biliary tree, duodenum, jejunum, and stomach, and to determine the gallbladder ejection fraction (GBEF) by using functional magnetic resonance cholangiography (MRC) with gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid (Gd-EOB-DTPA) in healthy volunteers. Materials and Methods: Forty subjects were included in this study. After conventional MRC, pre-fatty meal MRC (PRFM) was obtained at 30, 40, 50, and 60. min after contrast agent injection. Then, post-fatty meal MRC (POFM) was obtained every 10. min for 1. h. We assessed the PRFM and POFM for opacification of contrast agent in the first- and second-order intrahepatic ducts (IHDs) and the common bile duct (CBD). Contrast agent opacification in the cystic duct was assessed, and the percentage volume of contrast agent filling in the gallbladder (GB) was calculated on PRFM. We calculated the GBEF and assessed the presence of contrast agent in the GB, duodenum, jejunum, and stomach. Results: Thirty-six (90%) subjects showed grade 3 CBD opacification (visible contrast and well-defined bile duct border) on 60-min PRFM. Thirty-four (85%) subjects showed grade 3 first-order IHD opacification on 60-min PRFM. All (100%) subjects showed cystic duct opacification of contrast agent, and the average percentage volume of contrast agent filling in the GB was 68.81%. ±. 16.84% on 60-min PRFM. The GBEF at 30-min POFM was 35.00%. ±. 18.26%. Ten (25%) subjects had no contrast agent in the stomach and small bowel on all PRFMs. Twelve (30%) subjects had contrast medium in the stomach on PRFM and/or POFM. Conclusions: Functional MRC with Gd-EOB-DTPA can allow determining the distribution of bile in the biliary tree and small intestine, as well as the GBEF.

AB - Purpose: To describe the patterns of bile distribution in the biliary tree, duodenum, jejunum, and stomach, and to determine the gallbladder ejection fraction (GBEF) by using functional magnetic resonance cholangiography (MRC) with gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid (Gd-EOB-DTPA) in healthy volunteers. Materials and Methods: Forty subjects were included in this study. After conventional MRC, pre-fatty meal MRC (PRFM) was obtained at 30, 40, 50, and 60. min after contrast agent injection. Then, post-fatty meal MRC (POFM) was obtained every 10. min for 1. h. We assessed the PRFM and POFM for opacification of contrast agent in the first- and second-order intrahepatic ducts (IHDs) and the common bile duct (CBD). Contrast agent opacification in the cystic duct was assessed, and the percentage volume of contrast agent filling in the gallbladder (GB) was calculated on PRFM. We calculated the GBEF and assessed the presence of contrast agent in the GB, duodenum, jejunum, and stomach. Results: Thirty-six (90%) subjects showed grade 3 CBD opacification (visible contrast and well-defined bile duct border) on 60-min PRFM. Thirty-four (85%) subjects showed grade 3 first-order IHD opacification on 60-min PRFM. All (100%) subjects showed cystic duct opacification of contrast agent, and the average percentage volume of contrast agent filling in the GB was 68.81%. ±. 16.84% on 60-min PRFM. The GBEF at 30-min POFM was 35.00%. ±. 18.26%. Ten (25%) subjects had no contrast agent in the stomach and small bowel on all PRFMs. Twelve (30%) subjects had contrast medium in the stomach on PRFM and/or POFM. Conclusions: Functional MRC with Gd-EOB-DTPA can allow determining the distribution of bile in the biliary tree and small intestine, as well as the GBEF.

KW - Bile ducts

KW - Contrast medium

KW - Gastrointestinal tract

KW - Gd-EOB-DTPA

KW - Magnetic resonance

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U2 - 10.1016/j.mri.2014.01.003

DO - 10.1016/j.mri.2014.01.003

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JO - Magnetic Resonance Imaging

JF - Magnetic Resonance Imaging

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