Abstract
Two chondrogenic factors, Dex and TGF-β1, were incorporated into PLGA scaffolds and their chondrogenic potential was evaluated. The Dex-loaded PLGA scaffold was grafted with AA and heparin, the heparin-immobilized one was then reacted with TGF-β1, yielding a PLGA/Dex-TGF (PLGA/D/T) scaffold. The scaffolds were seeded with rabbit MSCs and cultured for 4 weeks. The results show that the scaffolds including chondrogenic factors strongly upregulated the expression of cartilage-specific genes and clearly displayed type-II collagen immunofluorescence. The functionalized PLGA scaffolds could provide an appropriate niche for chondrogenic differentiation of MSC without a constant medium supply of Dex and TGF-β1.
| Original language | English |
|---|---|
| Pages (from-to) | 221-229 |
| Number of pages | 9 |
| Journal | Macromolecular Bioscience |
| Volume | 9 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2009 Mar 10 |
ASJC Scopus subject areas
- Biotechnology
- Bioengineering
- Biomaterials
- Polymers and Plastics
- Materials Chemistry
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Park, K., Cho, K. J., Kim, J. J., Kim, I. H., & Han, D. K. (2009). Functional PLGA scaffolds for chondrogenesis of bone-marrow-derived mesenchymal stem cells. Macromolecular Bioscience, 9(3), 221-229. https://doi.org/10.1002/mabi.200800187