Functional PLGA scaffolds for chondrogenesis of bone-marrow-derived mesenchymal stem cells

Kwideok Park, Kyoung J. Cho, Jae J. Kim, Ik Hwan Kim, Dong Keun Han

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Two chondrogenic factors, Dex and TGF-β1, were incorporated into PLGA scaffolds and their chondrogenic potential was evaluated. The Dex-loaded PLGA scaffold was grafted with AA and heparin, the heparin-immobilized one was then reacted with TGF-β1, yielding a PLGA/Dex-TGF (PLGA/D/T) scaffold. The scaffolds were seeded with rabbit MSCs and cultured for 4 weeks. The results show that the scaffolds including chondrogenic factors strongly upregulated the expression of cartilage-specific genes and clearly displayed type-II collagen immunofluorescence. The functionalized PLGA scaffolds could provide an appropriate niche for chondrogenic differentiation of MSC without a constant medium supply of Dex and TGF-β1.

Original languageEnglish
Pages (from-to)221-229
Number of pages9
JournalMacromolecular Bioscience
Volume9
Issue number3
DOIs
Publication statusPublished - 2009 Mar 10

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Materials Chemistry
  • Polymers and Plastics

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