Abstract
The aim of this study is to investigate whether the functional polymorphisms in the promoter of matrix metalloproteinase-1 (MMP-1) and in the regulatory region of the monocyte chemoattractant protein-1 (MCP-1) gene are associated with susceptibility to rheumatoid arthritis (RA) and its clinical features. The MMP-1 1G/2G polymorphism and the MCP-1 promoter A/G polymorphism were determined by polymerase chain reaction-restriction fragment length polymorphism in 117 RA patients and 97 healthy controls. The genotype distribution of the MMP-1 promoter did not differ between RA patients and control subjects. However, in the 2G/2G genotype. ESR and Plat were higher than the 1G/1G genotype. The genotype distribution of the MCP-1 promoter did not differ between the RA and control groups. Clinically there was no significant difference among RA patients according to the MCP-1 promoter genotypes. Our data show that the functional promoter polymorphism in the MMP-1 promoter may not play an important role in the susceptibility of RA, but the polymorphism may be related to clinical phenotypes.
Original language | English |
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Pages (from-to) | 235-239 |
Number of pages | 5 |
Journal | Scandinavian Journal of Rheumatology |
Volume | 32 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2003 |
Externally published | Yes |
Keywords
- Matrix metalloproteinase-1
- Monocyte chemoattractant protein-1 polymorphisms
- Rheumatoid arthritis
ASJC Scopus subject areas
- Immunology and Allergy
- Rheumatology
- Immunology