Functions and evolution of selenoprotein methionine sulfoxide reductases

Byung Cheon Lee, Alexander Dikiy, Hwa Young Kim, Vadim N. Gladyshev

Research output: Contribution to journalReview article

112 Citations (Scopus)

Abstract

Methionine sulfoxide reductases (Msrs) are thiol-dependent enzymes which catalyze conversion of methionine sulfoxide to methionine. Three Msr families, MsrA, MsrB, and fRMsr, are known. MsrA and MsrB are responsible for the reduction of methionine-S-sulfoxide and methionine-R-sulfoxide residues in proteins, respectively, whereas fRMsr reduces free methionine-R-sulfoxide. Besides acting on proteins, MsrA can additionally reduce free methionine-S-sulfoxide. Some MsrAs and MsrBs evolved to utilize catalytic selenocysteine. This includes MsrB1, which is a major MsrB in cytosol and nucleus in mammalian cells. Specialized machinery is used for insertion of selenocysteine into MsrB1 and other selenoproteins at in-frame UGA codons. Selenocysteine offers catalytic advantage to the protein repair function of Msrs, but also makes these proteins dependent on the supply of selenium and requires adjustments in their strategies for regeneration of active enzymes. Msrs have roles in protecting cellular proteins from oxidative stress and through this function they may regulate lifespan in several model organisms.

Original languageEnglish
Pages (from-to)1471-1477
Number of pages7
JournalBiochimica et Biophysica Acta - General Subjects
Volume1790
Issue number11
DOIs
Publication statusPublished - 2009 Nov 1
Externally publishedYes

Fingerprint

Methionine Sulfoxide Reductases
sulfoxide
Selenoproteins
Selenocysteine
Methionine
Proteins
Oxidative stress
Terminator Codon
Enzymes
Selenium
Sulfhydryl Compounds
Cytosol
Machinery
Regeneration
Oxidative Stress
Repair
Cells
methionine sulfoxide

Keywords

  • Aging
  • Antioxidants
  • fRMsr
  • Methionine sulfoxide
  • MsrA
  • MsrB1
  • MsrB2
  • MsrB3
  • ROS
  • Selenocysteine
  • Selenoprotein

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology

Cite this

Functions and evolution of selenoprotein methionine sulfoxide reductases. / Lee, Byung Cheon; Dikiy, Alexander; Kim, Hwa Young; Gladyshev, Vadim N.

In: Biochimica et Biophysica Acta - General Subjects, Vol. 1790, No. 11, 01.11.2009, p. 1471-1477.

Research output: Contribution to journalReview article

Lee, Byung Cheon ; Dikiy, Alexander ; Kim, Hwa Young ; Gladyshev, Vadim N. / Functions and evolution of selenoprotein methionine sulfoxide reductases. In: Biochimica et Biophysica Acta - General Subjects. 2009 ; Vol. 1790, No. 11. pp. 1471-1477.
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