Fungal metabolites, sorbicillinoid polyketides and their effects on the activation of peroxisome proliferator-activated receptor γ

Dongho Lee, Jeong Hyung Lee, Xing Fu Cai, Jin Chul Shin, Kyeong Lee, Young Soo Hong, Jung Joon Lee

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

A new sorbicillinoid polyketide, dihydrotrichodimerol (2), along with known trichodimerol (1), and rezishanones C (3) and D (4) were isolated by bioassay-guided fractionation from an unidentified fungal strain. Dihydrotrichodimerol (2) specifically activated peroxisome proliferator- activated receptor γ with an ED50 value of 80 ng/ml as measured by a transactivation assay using a chimeric hPPAR/GAL4 system without affecting peroxisome proliferator-activated receptors α and δ. On the other hand, compounds 1 and 2 suppressed the production of tumor necrosis factor-α and nitric oxide in LPS-stimulated RAW264.7 cells to a similar extent.

Original languageEnglish
Pages (from-to)615-620
Number of pages6
JournalJournal of Antibiotics
Volume58
Issue number10
DOIs
Publication statusPublished - 2005 Oct

Keywords

  • Nitric oxide
  • Peroxisome proliferator-activated receptor γ
  • Sorbicillinoid
  • Trichodimerol derivative
  • Tumor necrosis factor-α

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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