Furanocoumarins from the Roots of Angelica dahurica with Inhibitory Activity against Intracellular Reactive Oxygen Species Accumulation

Unwoo Kang, Ah Reum Han, Yangkang So, Chang Hyun Jin, Seung Mok Ryu, Dongho Lee, Eun Kyoung Seo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Five new furanocoumarins, dahuribirin H (1), dahuribirin I (2), (2′S)-(+)-5-(2′-hydroxy-3′-methylbut-3′-enyloxy)-8-(3′′-methylbut-2″-enyloxy)psoralen (3), (2′R)-(+)-5-(2′,3′-epoxy-3′-methylbutoxy)-8-(3″-methylbut-2″-enyloxy)psoralen (4), and 5-methoxy-8-((Z)-4′-(3″-methylbutanoate)-3′-methylbut-2′-enyloxy)psoralen (5), along with 15 known compounds (6-20), were isolated from the roots of Angelica dahurica. The structures of the new compounds were elucidated by spectroscopic analysis, along with electronic circular dichroism calculations and Mosher ester analysis. Compounds 3, 4, 11, 13, and 16 reduced H2O2-induced cell death in HepG2 cells and attenuated reactive oxygen species (ROS) formation without showing cytotoxicity, suggesting that these compounds might have cytoprotective effects against H2O2-induced oxidative damage via ROS scavenging activities.

Original languageEnglish
Pages (from-to)2601-2607
Number of pages7
JournalJournal of Natural Products
Volume82
Issue number9
DOIs
Publication statusPublished - 2019 Sep 27

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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