G-protein β3 subunit gene 825C/T polymorphism is not associated with olanzapine-induced weight gain in Korean schizophrenic patients

Young Min Park, Young Cho Chung, Seung Hwan Lee, Kang Joon Lee, Hyun Kim, Jung Eun Choi, Seung Gul Kang, Min Soo Lee, Leen Kim, Heon Jeong Lee

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Objective: Weight gain is a Possible adverse effect of the use of antipsychotics, and is an important factor for long-term health and treatment compliance. Olanzapine, is an atypical antipsychotic known to cause considerable weight gain. A relationship between weight gain and the G protein β3 subunit gene (GNB3) 825C/T polymorphism has been reported. We therefore examined this possible association in a Korean schizophrenic patient group receiving olanzapine treatment. Methods: Weight and height measurements were obtained prior to starting olanzapine and meastapd again after long-term treatment. Genotyping for the 825C/T polymorphism was performed using a PCR-based method. Results: We found that long-term treatment with olanzapine resulted in mean gains in weight and body mass index (BMI) of 5.2 kg and 1.93 kg/ m2, respectively. There was a no significant difference in the mean body weight change from baseline to the endpoint after olanzapine treatment between the genotype groups (p=0.796). There were also no significant differences in genotype or allele frequencies between the severe weight-gain (more than 10%) and minimal weight-gain (less than 10%) groups (X2=0.037, VO.98; X2=0.020, p=0.89). Conclusion: The finding from this study thus does not support a relationship between the GNB3 825C/T polymorphism and weight gain in Korean schizophrenic patients receiving olanzapine treatment.

Original languageEnglish
Pages (from-to)39-43
Number of pages5
JournalPsychiatry Investigation
Issue number1
Publication statusPublished - 2009 Mar 1



  • Olanzapine
  • Polymorphism
  • Schizophrenia
  • Weight

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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