G protein β3 subunit, interleukin-10, and tumor necrosis factor-α gene polymorphisms in Koreans with irritable bowel syndrome

H. J. Lee, S. Y. Lee, J. E. Choi, J. H. Kim, I. K. Sung, H. S. Park, C. J. Jin

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Background: The association between irritable bowel syndrome (IBS) based on Rome III criteria and G protein β3 subunit (GNB3), interleukin (IL)-10, and tumor necrosis factor (TNF)-α gene polymorphisms is uncertain. Methods: Case and control subjects were recruited from Korean visitors to the Health Promotion Center and Digestive Disease Center for gastrointestinal endoscopy. G protein β3 subunit, IL-10, and TNF-α gene polymorphisms were genotyped using a polymerase chain reaction-based method. Multifactor dimensionality reduction (MDR) analysis was used to assess gene-gene interactions. Key Results: Genotype and allele frequencies of GNB3 showed marginal significance between the healthy controls and IBS patients (χ2 = 5.92, P = 0.052; χ2 = 3.76, P = 0.053). G protein β3 subunit T allele was more strongly correlated with IBS with constipation (12 of constipation-dominant type and 31 of mixed type) than with 51 diarrhea-dominant type and 88 normal subjects (χ2 = 13.91, P = 0.008). Multifactor dimensionality reduction analysis revealed that there were no significant interactions of GNB3, IL-10, and TNF-α gene variants with susceptibility to IBS (P > 0.05). Conclusions & Inferences: The results suggest that GNB3 825T allele might be associated with IBS with constipation in Koreans.

Original languageEnglish
Pages (from-to)758-763
Number of pages6
JournalNeurogastroenterology and Motility
Volume22
Issue number7
DOIs
Publication statusPublished - 2010 Jul

Keywords

  • G protein
  • Irritable bowel syndrome
  • Poly-morphism
  • Rome III criteria

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems
  • Gastroenterology

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