G protein β3 subunit, interleukin-10, and tumor necrosis factor-α gene polymorphisms in Koreans with irritable bowel syndrome

Heon-Jeong Lee, S. Y. Lee, J. E. Choi, J. H. Kim, I. K. Sung, H. S. Park, C. J. Jin

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Background: The association between irritable bowel syndrome (IBS) based on Rome III criteria and G protein β3 subunit (GNB3), interleukin (IL)-10, and tumor necrosis factor (TNF)-α gene polymorphisms is uncertain. Methods: Case and control subjects were recruited from Korean visitors to the Health Promotion Center and Digestive Disease Center for gastrointestinal endoscopy. G protein β3 subunit, IL-10, and TNF-α gene polymorphisms were genotyped using a polymerase chain reaction-based method. Multifactor dimensionality reduction (MDR) analysis was used to assess gene-gene interactions. Key Results: Genotype and allele frequencies of GNB3 showed marginal significance between the healthy controls and IBS patients (χ2 = 5.92, P = 0.052; χ2 = 3.76, P = 0.053). G protein β3 subunit T allele was more strongly correlated with IBS with constipation (12 of constipation-dominant type and 31 of mixed type) than with 51 diarrhea-dominant type and 88 normal subjects (χ2 = 13.91, P = 0.008). Multifactor dimensionality reduction analysis revealed that there were no significant interactions of GNB3, IL-10, and TNF-α gene variants with susceptibility to IBS (P > 0.05). Conclusions & Inferences: The results suggest that GNB3 825T allele might be associated with IBS with constipation in Koreans.

Original languageEnglish
Pages (from-to)758-763
Number of pages6
JournalNeurogastroenterology and Motility
Issue number7
Publication statusPublished - 2010 Jul 1



  • G protein
  • Irritable bowel syndrome
  • Poly-morphism
  • Rome III criteria

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Gastroenterology
  • Physiology
  • Medicine(all)

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