G-protein β3 subunit C825T polymorphism tends to be associated with seasonal variation in young male college students

Heon Jeong Lee; Seung Mo Sung; Chang Su Han; Yong Ku Kim; Seung Hyun Kim; Min Soo Lee; Sook Haeng Joe; In Kwa Jung; Leen Kim

doi:10.1159/000087559

G-protein β₃ subunit C825T polymorphism tends to be associated with seasonal variation in young male college students

Heon Jeong Lee, Seung Mo Sung, Chang Su Han, Yong Ku Kim, Seung Hyun Kim, Min Soo Lee, Sook Haeng Joe, In Kwa Jung, Leen Kim

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

This study investigated the relationship between G-protein β₃ subunit (GNB3) C825T polymorphism and seasonal variation in 189 young male college students. The subjects were genotyped for C825T and were evaluated by the Seasonality Pattern Assessment Questionnaire. The Global Seasonality Score (GSS) between the three genotypes revealed a marginal difference. The heterozygotes showed significantly higher seasonal variations in GSS than the homozygotes. The prevalence of heterozygotes tended to be higher in seasonals compared with normal subjects, although it was not statistically significant. These results suggest that GNB3 C825T polymorphism tends to be related to seasonal variation in mood and behavior in the normal population.

Original language	English
Pages (from-to)	135-139
Number of pages	5
Journal	Neuropsychobiology
Volume	52
Issue number	3
DOIs	https://doi.org/10.1159/000087559
Publication status	Published - 2005 Sept

Keywords

G-protein
Heterosis
Polymorphism
Seasonality

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1159/000087559

Cite this

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title = "G-protein β3 subunit C825T polymorphism tends to be associated with seasonal variation in young male college students",

abstract = "This study investigated the relationship between G-protein β3 subunit (GNB3) C825T polymorphism and seasonal variation in 189 young male college students. The subjects were genotyped for C825T and were evaluated by the Seasonality Pattern Assessment Questionnaire. The Global Seasonality Score (GSS) between the three genotypes revealed a marginal difference. The heterozygotes showed significantly higher seasonal variations in GSS than the homozygotes. The prevalence of heterozygotes tended to be higher in seasonals compared with normal subjects, although it was not statistically significant. These results suggest that GNB3 C825T polymorphism tends to be related to seasonal variation in mood and behavior in the normal population.",

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AU - Lee, Heon Jeong

AU - Sung, Seung Mo

AU - Han, Chang Su

AU - Kim, Yong Ku

AU - Kim, Seung Hyun

AU - Lee, Min Soo

AU - Joe, Sook Haeng

AU - Jung, In Kwa

AU - Kim, Leen

PY - 2005/9

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AB - This study investigated the relationship between G-protein β3 subunit (GNB3) C825T polymorphism and seasonal variation in 189 young male college students. The subjects were genotyped for C825T and were evaluated by the Seasonality Pattern Assessment Questionnaire. The Global Seasonality Score (GSS) between the three genotypes revealed a marginal difference. The heterozygotes showed significantly higher seasonal variations in GSS than the homozygotes. The prevalence of heterozygotes tended to be higher in seasonals compared with normal subjects, although it was not statistically significant. These results suggest that GNB3 C825T polymorphism tends to be related to seasonal variation in mood and behavior in the normal population.

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