G-protein β3 subunit C825T polymorphism tends to be associated with seasonal variation in young male college students

Heon-Jeong Lee, Seung Mo Sung, Changsu Han, Yong Ku Kim, Seung Hyun Kim, Min-Soo Lee, Sook Haeng Joe, In Kwa Jung, Leen Kim

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17 Citations (Scopus)


This study investigated the relationship between G-protein β3 subunit (GNB3) C825T polymorphism and seasonal variation in 189 young male college students. The subjects were genotyped for C825T and were evaluated by the Seasonality Pattern Assessment Questionnaire. The Global Seasonality Score (GSS) between the three genotypes revealed a marginal difference. The heterozygotes showed significantly higher seasonal variations in GSS than the homozygotes. The prevalence of heterozygotes tended to be higher in seasonals compared with normal subjects, although it was not statistically significant. These results suggest that GNB3 C825T polymorphism tends to be related to seasonal variation in mood and behavior in the normal population.

Original languageEnglish
Pages (from-to)135-139
Number of pages5
Issue number3
Publication statusPublished - 2005 Sep 1



  • G-protein
  • Heterosis
  • Polymorphism
  • Seasonality

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Psychology(all)

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