GABA as a rising gliotransmitter

Bo Eun Yoon, Changjoon Lee

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Gamma-amino butyric acid (GABA) is the major inhibitory neurotransmitter that is known to be synthesized and released from GABAergic neurons in the brain. However, recent studies have shown that not only neurons but also astrocytes contain a considerable amount of GABA that can be released and activate GABA receptors in neighboring neurons. These exciting new findings for glial GABA raise further interesting questions about the source of GABA, its mechanism of release and regulation and the functional role of glial GABA. In this review, we highlight recent studies that identify the presence and release of GABA in glial cells, we show several proposed potential pathways for accumulation and modulation of glial intracellular and extracellular GABA content, and finally we discuss functional roles for glial GABA in the brain.

Original languageEnglish
Article number141
JournalFrontiers in Neural Circuits
Volume8
Issue numberDEC
DOIs
Publication statusPublished - 2014 Dec 17
Externally publishedYes

Fingerprint

Butyric Acid
Neuroglia
Amino Acid Receptors
Neurons
GABAergic Neurons
Brain
Astrocytes
Neurotransmitter Agents

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Cellular and Molecular Neuroscience
  • Sensory Systems
  • Cognitive Neuroscience

Cite this

GABA as a rising gliotransmitter. / Yoon, Bo Eun; Lee, Changjoon.

In: Frontiers in Neural Circuits, Vol. 8, No. DEC, 141, 17.12.2014.

Research output: Contribution to journalArticle

Yoon, Bo Eun ; Lee, Changjoon. / GABA as a rising gliotransmitter. In: Frontiers in Neural Circuits. 2014 ; Vol. 8, No. DEC.
@article{6db9dd1a35024757a3762d37b84a6453,
title = "GABA as a rising gliotransmitter",
abstract = "Gamma-amino butyric acid (GABA) is the major inhibitory neurotransmitter that is known to be synthesized and released from GABAergic neurons in the brain. However, recent studies have shown that not only neurons but also astrocytes contain a considerable amount of GABA that can be released and activate GABA receptors in neighboring neurons. These exciting new findings for glial GABA raise further interesting questions about the source of GABA, its mechanism of release and regulation and the functional role of glial GABA. In this review, we highlight recent studies that identify the presence and release of GABA in glial cells, we show several proposed potential pathways for accumulation and modulation of glial intracellular and extracellular GABA content, and finally we discuss functional roles for glial GABA in the brain.",
keywords = "Astrocyte, Glial GABA, Gliotransmitter, MAOB, Tonic inhibition",
author = "Yoon, {Bo Eun} and Changjoon Lee",
year = "2014",
month = "12",
day = "17",
doi = "10.3389/fncir.2014.00141",
language = "English",
volume = "8",
journal = "Frontiers in Neural Circuits",
issn = "1662-5110",
publisher = "Frontiers Research Foundation",
number = "DEC",

}

TY - JOUR

T1 - GABA as a rising gliotransmitter

AU - Yoon, Bo Eun

AU - Lee, Changjoon

PY - 2014/12/17

Y1 - 2014/12/17

N2 - Gamma-amino butyric acid (GABA) is the major inhibitory neurotransmitter that is known to be synthesized and released from GABAergic neurons in the brain. However, recent studies have shown that not only neurons but also astrocytes contain a considerable amount of GABA that can be released and activate GABA receptors in neighboring neurons. These exciting new findings for glial GABA raise further interesting questions about the source of GABA, its mechanism of release and regulation and the functional role of glial GABA. In this review, we highlight recent studies that identify the presence and release of GABA in glial cells, we show several proposed potential pathways for accumulation and modulation of glial intracellular and extracellular GABA content, and finally we discuss functional roles for glial GABA in the brain.

AB - Gamma-amino butyric acid (GABA) is the major inhibitory neurotransmitter that is known to be synthesized and released from GABAergic neurons in the brain. However, recent studies have shown that not only neurons but also astrocytes contain a considerable amount of GABA that can be released and activate GABA receptors in neighboring neurons. These exciting new findings for glial GABA raise further interesting questions about the source of GABA, its mechanism of release and regulation and the functional role of glial GABA. In this review, we highlight recent studies that identify the presence and release of GABA in glial cells, we show several proposed potential pathways for accumulation and modulation of glial intracellular and extracellular GABA content, and finally we discuss functional roles for glial GABA in the brain.

KW - Astrocyte

KW - Glial GABA

KW - Gliotransmitter

KW - MAOB

KW - Tonic inhibition

UR - http://www.scopus.com/inward/record.url?scp=84919442256&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84919442256&partnerID=8YFLogxK

U2 - 10.3389/fncir.2014.00141

DO - 10.3389/fncir.2014.00141

M3 - Article

VL - 8

JO - Frontiers in Neural Circuits

JF - Frontiers in Neural Circuits

SN - 1662-5110

IS - DEC

M1 - 141

ER -