Gabapentin relieves mechanical, warm and cold allodynia in a rat model of peripheral neuropathy

Seung Keun Back, Sang Youn Won, Seung Kil Hong, Heung Sik Na

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Although recent studies demonstrated the relieving effect of gabapentin on neuropathic pain, the effect has not been sufficiently examined. In the present study, we investigated the effect of gabapentin on mechanical, warm and cold allodynia in a rat model of peripheral neuropathy.Under enflurane anesthesia, animals were subjected to the partial injury of the nerves innervating the tail. Behavioral tests for mechanical, cold and warm allodynia on the tail were performed by von Frey hair (2.0 g) stimulation, 4 and 40°C water immersion, respectively. Intraperitoneal injection of gabapentin (30, 100, 300 mg/kg) significantly alleviated mechanical, warm and cold allodynia in a dose-dependent manner. Our results suggest that gabapentin is an effective agent against mechanical, warm and cold allodynia in a rat model of peripheral neuropathy.

Original languageEnglish
Pages (from-to)341-344
Number of pages4
JournalNeuroscience Letters
Volume368
Issue number3
DOIs
Publication statusPublished - 2004 Sep 30

Keywords

  • Allodynia
  • Gabapentin
  • Neuropathic pain
  • Peripheral neuropathy

ASJC Scopus subject areas

  • Neuroscience(all)

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