Abstract
Although recent studies demonstrated the relieving effect of gabapentin on neuropathic pain, the effect has not been sufficiently examined. In the present study, we investigated the effect of gabapentin on mechanical, warm and cold allodynia in a rat model of peripheral neuropathy.Under enflurane anesthesia, animals were subjected to the partial injury of the nerves innervating the tail. Behavioral tests for mechanical, cold and warm allodynia on the tail were performed by von Frey hair (2.0 g) stimulation, 4 and 40°C water immersion, respectively. Intraperitoneal injection of gabapentin (30, 100, 300 mg/kg) significantly alleviated mechanical, warm and cold allodynia in a dose-dependent manner. Our results suggest that gabapentin is an effective agent against mechanical, warm and cold allodynia in a rat model of peripheral neuropathy.
| Original language | English |
|---|---|
| Pages (from-to) | 341-344 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 368 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2004 Sep 30 |
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Keywords
- Allodynia
- Gabapentin
- Neuropathic pain
- Peripheral neuropathy
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Gabapentin relieves mechanical, warm and cold allodynia in a rat model of peripheral neuropathy. / Back, Seung Keun; Won, Sang Youn; Hong, Seung Kil; Na, Heung Sik.
In: Neuroscience Letters, Vol. 368, No. 3, 30.09.2004, p. 341-344.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gabapentin relieves mechanical, warm and cold allodynia in a rat model of peripheral neuropathy
AU - Back, Seung Keun
AU - Won, Sang Youn
AU - Hong, Seung Kil
AU - Na, Heung Sik
PY - 2004/9/30
Y1 - 2004/9/30
N2 - Although recent studies demonstrated the relieving effect of gabapentin on neuropathic pain, the effect has not been sufficiently examined. In the present study, we investigated the effect of gabapentin on mechanical, warm and cold allodynia in a rat model of peripheral neuropathy.Under enflurane anesthesia, animals were subjected to the partial injury of the nerves innervating the tail. Behavioral tests for mechanical, cold and warm allodynia on the tail were performed by von Frey hair (2.0 g) stimulation, 4 and 40°C water immersion, respectively. Intraperitoneal injection of gabapentin (30, 100, 300 mg/kg) significantly alleviated mechanical, warm and cold allodynia in a dose-dependent manner. Our results suggest that gabapentin is an effective agent against mechanical, warm and cold allodynia in a rat model of peripheral neuropathy.
AB - Although recent studies demonstrated the relieving effect of gabapentin on neuropathic pain, the effect has not been sufficiently examined. In the present study, we investigated the effect of gabapentin on mechanical, warm and cold allodynia in a rat model of peripheral neuropathy.Under enflurane anesthesia, animals were subjected to the partial injury of the nerves innervating the tail. Behavioral tests for mechanical, cold and warm allodynia on the tail were performed by von Frey hair (2.0 g) stimulation, 4 and 40°C water immersion, respectively. Intraperitoneal injection of gabapentin (30, 100, 300 mg/kg) significantly alleviated mechanical, warm and cold allodynia in a dose-dependent manner. Our results suggest that gabapentin is an effective agent against mechanical, warm and cold allodynia in a rat model of peripheral neuropathy.
KW - Allodynia
KW - Gabapentin
KW - Neuropathic pain
KW - Peripheral neuropathy
UR - http://www.scopus.com/inward/record.url?scp=4544337930&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4544337930&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2004.07.091
DO - 10.1016/j.neulet.2004.07.091
M3 - Article
VL - 368
SP - 341
EP - 344
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 3
ER -