Gadobutrol-enhanced, three-dimensional, dynamic MR imaging with MR cholangiography for the preoperative evaluation of bile duct cancer

Inseon Ryoo, Jeong Min Lee, Yong Eun Chung, Hee Sun Park, Se Hyung Kim, Joon Koo Han, Byung Ihn Choi

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Purpose:To evaluate the diagnostic performance of 1.0-M gadobutrol-enhanced, 3-dimensional (3D), dynamic MR images with 3D-MR cholangiography (MRC) in the preoperative evaluation of bile duct cancer staging and resectability. Materials and Methods:Our institutional review board approved this retrospective study. Sixty patients (46 male, 14 female; mean age 65.9 years; range, 45-77 years) with surgically and pathologically proven bile duct cancers, were included in this study. Two gastrointestinal radiologists evaluated the biliary MR images, including 3D-MRC and gadobutrol-enhanced, dynamic images, using a 3D-gradient echo (GRE) technique, regarding the longitudinal tumor extent, vascular involvement of the bile duct cancer, lymph node metastasis, and tumor resectability. The results were compared with the surgical and pathology findings used as the reference standards. Results: The area under the receiver operating characteristic curve (Az) of the 2 reviewers was 0.95 and 0.93, respectively, for evaluation of the involvement of both secondary biliary confluences and 0.85 and 0.84, respectively, for assessment of the intrapancreatic duct. For determining the tumor resectability, the overall accuracy was 0.93 and 0.88, respectively, whereas for assessment of the vascular involvement, the Az values were 0.92 for reviewer 1 and 0.70 for reviewer 2 for the portal vein evaluation, and 0.99 for reviewer 1 and 0.76 for reviewer 2 for the hepatic artery evaluation. In the assessment of lymph node metastasis, the overall accuracy was approximately 0.77 for each reviewer. Conclusion: One-molar, gadobutrol-enhanced, dynamic imaging, using a 3D-GRE technique with isotropic 3D-MRC showed excellent diagnostic capability for assessing the longitudinal extent and tumor resectability of bile duct cancer, although it generally underestimated the tumor involvement of vessels and lymph nodes.

Original languageEnglish
Pages (from-to)217-224
Number of pages8
JournalInvestigative Radiology
Volume45
Issue number4
DOIs
Publication statusPublished - 2010 Apr 1
Externally publishedYes

Fingerprint

Bile Duct Neoplasms
Cholangiography
Lymph Nodes
Neoplasms
Blood Vessels
Neoplasm Metastasis
Surgical Pathology
Neoplasm Staging
Research Ethics Committees
Hepatic Artery
Portal Vein
ROC Curve
Retrospective Studies
gadobutrol

Keywords

  • Bile duct cancer
  • Gadobutrol
  • MR cholangiography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Gadobutrol-enhanced, three-dimensional, dynamic MR imaging with MR cholangiography for the preoperative evaluation of bile duct cancer. / Ryoo, Inseon; Lee, Jeong Min; Chung, Yong Eun; Park, Hee Sun; Kim, Se Hyung; Han, Joon Koo; Choi, Byung Ihn.

In: Investigative Radiology, Vol. 45, No. 4, 01.04.2010, p. 217-224.

Research output: Contribution to journalArticle

Ryoo, Inseon ; Lee, Jeong Min ; Chung, Yong Eun ; Park, Hee Sun ; Kim, Se Hyung ; Han, Joon Koo ; Choi, Byung Ihn. / Gadobutrol-enhanced, three-dimensional, dynamic MR imaging with MR cholangiography for the preoperative evaluation of bile duct cancer. In: Investigative Radiology. 2010 ; Vol. 45, No. 4. pp. 217-224.
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AU - Ryoo, Inseon

AU - Lee, Jeong Min

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AU - Kim, Se Hyung

AU - Han, Joon Koo

AU - Choi, Byung Ihn

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