Gadolinium-based nanoparticles for highly efficient T1-weighted magnetic resonance imaging

Eun Kyung Lim, Byunghoon Kang, Yuna Choi, Eunji Jang, Seungmin Han, Kwangyeol Lee, Jin Suck Suh, Seungjoo Haam, Yong Min Huh

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We developed Pyrene-Gadolinium (Py-Gd) nanoparticles as pH-sensitive magnetic resonance imaging (MRI) contrast agents capable of showing a high-Mr signal in cancer-specific environments, such as acidic conditions. Py-Gd nanoparticles were prepared by coating Py-Gd, which is a complex of gadolinium with pyrenyl molecules, with pyrenyl polyethyleneglycol PEG using a nano-emulsion method. These particles show better longitudinal relaxation time (T1) MR signals in acidic conditions than they do in neutral conditions. Furthermore, the particles exhibit biocompatibility and MR contrast effects in both in vitro and in vivo studies. From these results, we confirm that Py-Gd nanoparticles have the potential to be applied for accurate cancer diagnosis and therapy.

Original languageEnglish
Article number245103
JournalNanotechnology
Volume25
Issue number24
DOIs
Publication statusPublished - 2014 Jun 20

Keywords

  • gadolinium
  • high sensitivity
  • imaging agent
  • magnetic resonance image

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering
  • Electrical and Electronic Engineering

Fingerprint Dive into the research topics of 'Gadolinium-based nanoparticles for highly efficient T1-weighted magnetic resonance imaging'. Together they form a unique fingerprint.

  • Cite this

    Lim, E. K., Kang, B., Choi, Y., Jang, E., Han, S., Lee, K., Suh, J. S., Haam, S., & Huh, Y. M. (2014). Gadolinium-based nanoparticles for highly efficient T1-weighted magnetic resonance imaging. Nanotechnology, 25(24), [245103]. https://doi.org/10.1088/0957-4484/25/24/245103