Gadolinium complex of 125I/127I-RGD-DOTA conjugate as a tumor-targeting SPECT/MR bimodal imaging probe

Ji Ae Park, Jung Young Kim, Yong Jin Lee, Wonho Lee, Sang Moo Lim, Tae Jeong Kim, Jeongsoo Yoo, Yongmin Chang, Kyeong Min Kim

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


The work describes the synthesis and in vivo application of [Gd(L)(H 2O)]·xH2O, where L is a (125I/ 127I-RGD)- DOTA conjugate, as a tumor-targeting SPECT/MR bimodal imaging probe. Here, (125I/127I-RGD)-DOTA signifies a "cocktail mixture" of radioisotopic (1a, L = 125I-RGD-DOTA) and natural (1b, L = 127I-RGD-DOTA) Gd complexes. The two complexes are chemically equivalent as revealed by HPLC, and their cocktail mixture exhibits the integrin-specific tumor enhancement, demonstrating that they constitute essentially a single bimodal imaging probe. Employment of a cocktail mixture thus proves to be a sole and practical approach to overcome the sensitivity difference problem between MRI and SPECT.

Original languageEnglish
Pages (from-to)216-219
Number of pages4
JournalACS Medicinal Chemistry Letters
Issue number2
Publication statusPublished - 2013 Feb 14
Externally publishedYes


  • RGD peptide
  • dual modality
  • small molecule
  • tumor targeting

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


Dive into the research topics of 'Gadolinium complex of <sup>125</sup>I/<sup>127</sup>I-RGD-DOTA conjugate as a tumor-targeting SPECT/MR bimodal imaging probe'. Together they form a unique fingerprint.

Cite this