Gadolinium complex of 125I/127I-RGD-DOTA conjugate as a tumor-targeting SPECT/MR bimodal imaging probe

Ji Ae Park, Jung Young Kim, Yong Jin Lee, Wonho Lee, Sang Moo Lim, Tae Jeong Kim, Jeongsoo Yoo, Yongmin Chang, Kyeong Min Kim

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The work describes the synthesis and in vivo application of [Gd(L)(H 2O)]·xH2O, where L is a (125I/ 127I-RGD)- DOTA conjugate, as a tumor-targeting SPECT/MR bimodal imaging probe. Here, (125I/127I-RGD)-DOTA signifies a "cocktail mixture" of radioisotopic (1a, L = 125I-RGD-DOTA) and natural (1b, L = 127I-RGD-DOTA) Gd complexes. The two complexes are chemically equivalent as revealed by HPLC, and their cocktail mixture exhibits the integrin-specific tumor enhancement, demonstrating that they constitute essentially a single bimodal imaging probe. Employment of a cocktail mixture thus proves to be a sole and practical approach to overcome the sensitivity difference problem between MRI and SPECT.

Original languageEnglish
Pages (from-to)216-219
Number of pages4
JournalACS Medicinal Chemistry Letters
Volume4
Issue number2
DOIs
Publication statusPublished - 2013 Feb 14
Externally publishedYes

Keywords

  • dual modality
  • RGD peptide
  • small molecule
  • SPECT/MR
  • tumor targeting

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Park, J. A., Kim, J. Y., Lee, Y. J., Lee, W., Lim, S. M., Kim, T. J., Yoo, J., Chang, Y., & Kim, K. M. (2013). Gadolinium complex of 125I/127I-RGD-DOTA conjugate as a tumor-targeting SPECT/MR bimodal imaging probe. ACS Medicinal Chemistry Letters, 4(2), 216-219. https://doi.org/10.1021/ml3003499