Gadolinium complex of 125I/127I-RGD-DOTA conjugate as a tumor-targeting SPECT/MR bimodal imaging probe

Ji Ae Park; Jung Young Kim; Yong Jin Lee; Wonho Lee; Sang Moo Lim; Tae Jeong Kim; Jeongsoo Yoo; Yongmin Chang; Kyeong Min Kim

doi:10.1021/ml3003499

Gadolinium complex of ¹²⁵I/¹²⁷I-RGD-DOTA conjugate as a tumor-targeting SPECT/MR bimodal imaging probe

Ji Ae Park, Jung Young Kim, Yong Jin Lee, Wonho Lee, Sang Moo Lim, Tae Jeong Kim, Jeongsoo Yoo, Yongmin Chang, Kyeong Min Kim

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

The work describes the synthesis and in vivo application of [Gd(L)(H ₂O)]·xH₂O, where L is a (¹²⁵I/ ¹²⁷I-RGD)- DOTA conjugate, as a tumor-targeting SPECT/MR bimodal imaging probe. Here, (¹²⁵I/¹²⁷I-RGD)-DOTA signifies a "cocktail mixture" of radioisotopic (1a, L = ¹²⁵I-RGD-DOTA) and natural (1b, L = ¹²⁷I-RGD-DOTA) Gd complexes. The two complexes are chemically equivalent as revealed by HPLC, and their cocktail mixture exhibits the integrin-specific tumor enhancement, demonstrating that they constitute essentially a single bimodal imaging probe. Employment of a cocktail mixture thus proves to be a sole and practical approach to overcome the sensitivity difference problem between MRI and SPECT.

Original language	English
Pages (from-to)	216-219
Number of pages	4
Journal	ACS Medicinal Chemistry Letters
Volume	4
Issue number	2
DOIs	https://doi.org/10.1021/ml3003499
Publication status	Published - 2013 Feb 14
Externally published	Yes

Keywords

RGD peptide
SPECT/MR
dual modality
small molecule
tumor targeting

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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Gadolinium complex of ¹²⁵I/¹²⁷I-RGD-DOTA conjugate as a tumor-targeting SPECT/MR bimodal imaging probe. / Park, Ji Ae; Kim, Jung Young; Lee, Yong Jin; Lee, Wonho; Lim, Sang Moo; Kim, Tae Jeong; Yoo, Jeongsoo; Chang, Yongmin; Kim, Kyeong Min.

In: ACS Medicinal Chemistry Letters, Vol. 4, No. 2, 14.02.2013, p. 216-219.

Research output: Contribution to journal › Article › peer-review

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