Abstract
The work describes the synthesis and in vivo application of [Gd(L)(H 2O)]·xH2O, where L is a (125I/ 127I-RGD)- DOTA conjugate, as a tumor-targeting SPECT/MR bimodal imaging probe. Here, (125I/127I-RGD)-DOTA signifies a "cocktail mixture" of radioisotopic (1a, L = 125I-RGD-DOTA) and natural (1b, L = 127I-RGD-DOTA) Gd complexes. The two complexes are chemically equivalent as revealed by HPLC, and their cocktail mixture exhibits the integrin-specific tumor enhancement, demonstrating that they constitute essentially a single bimodal imaging probe. Employment of a cocktail mixture thus proves to be a sole and practical approach to overcome the sensitivity difference problem between MRI and SPECT.
Original language | English |
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Pages (from-to) | 216-219 |
Number of pages | 4 |
Journal | ACS Medicinal Chemistry Letters |
Volume | 4 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2013 Feb 14 |
Externally published | Yes |
Keywords
- RGD peptide
- SPECT/MR
- dual modality
- small molecule
- tumor targeting
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry