Gadolinium complex of 125I/127I-RGD-DOTA conjugate as a tumor-targeting SPECT/MR bimodal imaging probe

Ji Ae Park; Jung Young Kim; Yong Jin Lee; Wonho Lee; Sang Moo Lim; Tae Jeong Kim; Jeongsoo Yoo; Yongmin Chang; Kyeong Min Kim

doi:10.1021/ml3003499

Gadolinium complex of ¹²⁵I/¹²⁷I-RGD-DOTA conjugate as a tumor-targeting SPECT/MR bimodal imaging probe

Ji Ae Park, Jung Young Kim, Yong Jin Lee, Wonho Lee, Sang Moo Lim, Tae Jeong Kim, Jeongsoo Yoo, Yongmin Chang, Kyeong Min Kim

Research output: Contribution to journal › Article

22 Citations (Scopus)

Abstract

The work describes the synthesis and in vivo application of [Gd(L)(H ₂O)]·xH₂O, where L is a (¹²⁵I/ ¹²⁷I-RGD)- DOTA conjugate, as a tumor-targeting SPECT/MR bimodal imaging probe. Here, (¹²⁵I/¹²⁷I-RGD)-DOTA signifies a "cocktail mixture" of radioisotopic (1a, L = ¹²⁵I-RGD-DOTA) and natural (1b, L = ¹²⁷I-RGD-DOTA) Gd complexes. The two complexes are chemically equivalent as revealed by HPLC, and their cocktail mixture exhibits the integrin-specific tumor enhancement, demonstrating that they constitute essentially a single bimodal imaging probe. Employment of a cocktail mixture thus proves to be a sole and practical approach to overcome the sensitivity difference problem between MRI and SPECT.

Original language	English
Pages (from-to)	216-219
Number of pages	4
Journal	ACS Medicinal Chemistry Letters
Volume	4
Issue number	2
DOIs	https://doi.org/10.1021/ml3003499
Publication status	Published - 2013 Feb 14
Externally published	Yes

Keywords

dual modality
RGD peptide
small molecule
SPECT/MR
tumor targeting

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1021/ml3003499

Cite this

Park, J. A., Kim, J. Y., Lee, Y. J., Lee, W., Lim, S. M., Kim, T. J., Yoo, J., Chang, Y., & Kim, K. M. (2013). Gadolinium complex of ¹²⁵I/¹²⁷I-RGD-DOTA conjugate as a tumor-targeting SPECT/MR bimodal imaging probe. ACS Medicinal Chemistry Letters, 4(2), 216-219. https://doi.org/10.1021/ml3003499

@article{02ec49cbca8649bc8ada54330c5aa46d,

title = "Gadolinium complex of 125I/127I-RGD-DOTA conjugate as a tumor-targeting SPECT/MR bimodal imaging probe",

abstract = "The work describes the synthesis and in vivo application of [Gd(L)(H 2O)]·xH2O, where L is a (125I/ 127I-RGD)- DOTA conjugate, as a tumor-targeting SPECT/MR bimodal imaging probe. Here, (125I/127I-RGD)-DOTA signifies a {"}cocktail mixture{"} of radioisotopic (1a, L = 125I-RGD-DOTA) and natural (1b, L = 127I-RGD-DOTA) Gd complexes. The two complexes are chemically equivalent as revealed by HPLC, and their cocktail mixture exhibits the integrin-specific tumor enhancement, demonstrating that they constitute essentially a single bimodal imaging probe. Employment of a cocktail mixture thus proves to be a sole and practical approach to overcome the sensitivity difference problem between MRI and SPECT.",

keywords = "dual modality, RGD peptide, small molecule, SPECT/MR, tumor targeting",

author = "Park, {Ji Ae} and Kim, {Jung Young} and Lee, {Yong Jin} and Wonho Lee and Lim, {Sang Moo} and Kim, {Tae Jeong} and Jeongsoo Yoo and Yongmin Chang and Kim, {Kyeong Min}",

year = "2013",

month = feb,

day = "14",

doi = "10.1021/ml3003499",

language = "English",

volume = "4",

pages = "216--219",

journal = "ACS Medicinal Chemistry Letters",

issn = "1948-5875",

publisher = "American Chemical Society",

number = "2",

}

TY - JOUR

T1 - Gadolinium complex of 125I/127I-RGD-DOTA conjugate as a tumor-targeting SPECT/MR bimodal imaging probe

AU - Park, Ji Ae

AU - Kim, Jung Young

AU - Lee, Yong Jin

AU - Lee, Wonho

AU - Lim, Sang Moo

AU - Kim, Tae Jeong

AU - Yoo, Jeongsoo

AU - Chang, Yongmin

AU - Kim, Kyeong Min

PY - 2013/2/14

Y1 - 2013/2/14

N2 - The work describes the synthesis and in vivo application of [Gd(L)(H 2O)]·xH2O, where L is a (125I/ 127I-RGD)- DOTA conjugate, as a tumor-targeting SPECT/MR bimodal imaging probe. Here, (125I/127I-RGD)-DOTA signifies a "cocktail mixture" of radioisotopic (1a, L = 125I-RGD-DOTA) and natural (1b, L = 127I-RGD-DOTA) Gd complexes. The two complexes are chemically equivalent as revealed by HPLC, and their cocktail mixture exhibits the integrin-specific tumor enhancement, demonstrating that they constitute essentially a single bimodal imaging probe. Employment of a cocktail mixture thus proves to be a sole and practical approach to overcome the sensitivity difference problem between MRI and SPECT.

AB - The work describes the synthesis and in vivo application of [Gd(L)(H 2O)]·xH2O, where L is a (125I/ 127I-RGD)- DOTA conjugate, as a tumor-targeting SPECT/MR bimodal imaging probe. Here, (125I/127I-RGD)-DOTA signifies a "cocktail mixture" of radioisotopic (1a, L = 125I-RGD-DOTA) and natural (1b, L = 127I-RGD-DOTA) Gd complexes. The two complexes are chemically equivalent as revealed by HPLC, and their cocktail mixture exhibits the integrin-specific tumor enhancement, demonstrating that they constitute essentially a single bimodal imaging probe. Employment of a cocktail mixture thus proves to be a sole and practical approach to overcome the sensitivity difference problem between MRI and SPECT.

KW - dual modality

KW - RGD peptide

KW - small molecule

KW - SPECT/MR

KW - tumor targeting

UR - http://www.scopus.com/inward/record.url?scp=84873940870&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873940870&partnerID=8YFLogxK

U2 - 10.1021/ml3003499

DO - 10.1021/ml3003499

M3 - Article

AN - SCOPUS:84873940870

VL - 4

SP - 216

EP - 219

JO - ACS Medicinal Chemistry Letters

JF - ACS Medicinal Chemistry Letters

SN - 1948-5875

IS - 2

ER -