Gadoxetic acid (Gd-EOB-DTPA)-enhanced mri versus gadobenate dimeglumine (Gd-BOPTA)-enhanced MRI for preoperatively detecting hepatocellular carcinoma: An initial experience

Yulri Park, Seong Hyun Kim, Seung Hoon Kim, Yong Hwan Jeon, Jongmee Lee, Min Ju Kim, Dongil Choi, Won Jae Lee, Heejung Kim, Ji Hyun Koo, Hyo Keun Lim

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31 Citations (Scopus)

Abstract

Objective: This study was designed to compare the diagnostic performance of gadoxetic acid-enhanced magnetic resonance imaging (MRI) with gadobenate dimeglumine-enhanced MRI for preoperatively detecting hepatocellular carcinoma (HCC). Materials and Methods: Eighteen consecutive patients (17 men and one woman, age range: 31-73 years) with 22 HCCs underwent examinations with gadoxetic acid enhanced MRI and gadobenate dimeglumine-enhanced MRI on a 3.0-Tesla unit. The diagnosis of HCC was established after surgical resection and pathological conformation. Three observers independently reviewed each MR image in a random order on a tumor-by-tumor basis. The diagnostic accuracy of these techniques for the detection of HCC was assessed by performing an alternative free-response receiver operating characteristic (ROC) analysis. The sensitivity and positive predictive values were evaluated. Results: The average value of the area under the ROC curve (Az) for gadoxetic acid enhanced MRI (0.887) was not significantly different from the Az (0.899) for gadobenate dimeglumine-enhanced MRI (p > 0.05). The overall sensitivities of gadoxetic acid enhanced MRI and gadobenate dimeglumine-enhanced MRI were 80% and 83%, respectively, with no significant difference (p > 0.05). The differences of the positive predictive values for the two contrast agents for each observer were not statistically significant (p > 0.05). Conclusion: The diagnostic performance of gadoxetic acid-enhanced MRI and gadobenate dimeglumine-enhanced MRI for preoperatively detecting HCC is quite similar.

Original languageEnglish
Pages (from-to)433-440
Number of pages8
JournalKorean journal of radiology
Volume11
Issue number4
DOIs
Publication statusPublished - 2010 Jul

Keywords

  • Gadobenate dimeglumine-enhanced MRI
  • Gadoxetic acid-enhanced MRI
  • Hepatocellular carcinoma (HCC)

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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