Galactose-carrying polymers as extracellular matrices for liver tissue engineering

C. S. Cho, S. J. Seo, I. K. Park, Soo Hyun Kim, T. H. Kim, T. Hoshiba, I. Harada, T. Akaike

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145 Citations (Scopus)

Abstract

Extracellular matrix (ECM) plays important roles in tissue engineering because cellular growth and differentiation, in the two-dimensional cell culture as well as in the three-dimensional space of the developing organism, require ECM with which the cells can interact. Especially, the bioartificial liver-assist device or regeneration of the liver-tissue substitutes for liver tissue engineering requires a suitable ECM for hepatocyte culture because hepatocytes are anchorage-dependent cells and are highly sensitive to the ECM milieu for the maintenance of their viability and differentiated functions. Galactose-carrying synthetic ECMs derived from synthetic polymers and natural polymers bind hepatocytes through a receptor-mediated mechanism, resulting in enhanced hepatocyte functions. Attachment and functions of hepatocytes were affected by physico-chemical properties including ECM geometry as well as the type, density and orientation of galactose. Also, cellular environment, medium composition and dynamic culture system influenced liver-specific functions of hepatocytes beside ECM.

Original languageEnglish
Pages (from-to)576-585
Number of pages10
JournalBiomaterials
Volume27
Issue number4
DOIs
Publication statusPublished - 2006 Feb 1
Externally publishedYes

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Keywords

  • Asialoglycoprotein receptors
  • Extracellular matrix
  • Galactose
  • Hepatocyte
  • Tissue engineering

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

Cite this

Cho, C. S., Seo, S. J., Park, I. K., Kim, S. H., Kim, T. H., Hoshiba, T., Harada, I., & Akaike, T. (2006). Galactose-carrying polymers as extracellular matrices for liver tissue engineering. Biomaterials, 27(4), 576-585. https://doi.org/10.1016/j.biomaterials.2005.06.008