Gamma-irradiated chrysin improves anticancer activity in HT-29 colon cancer cells through mitochondria-related pathway

Ha Yeon Song; Hye Min Kim; Sajid Mushtaq; Woo Sik Kim; Young Jun Kim; Seung Taik Lim; Eui Baek Byun

doi:10.1089/jmf.2018.4320

Gamma-irradiated chrysin improves anticancer activity in HT-29 colon cancer cells through mitochondria-related pathway

Ha Yeon Song, Hye Min Kim, Sajid Mushtaq, Woo Sik Kim, Young Jun Kim, Seung Taik Lim, Eui Baek Byun

Department of Biotechnology

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Irradiation technology can improve the biological activities of natural molecules through a structural modification. This study was conducted to investigate the enhancement of the anticancer effects of chrysin upon exposure to gamma irradiation. Gamma irradiation induces the production of new radiolytic peaks simultaneously with the decrease of the chrysin peak, which increases the cytotoxicity in HT-29 human colon cancer cells. An isolated chrysin derivative (CM1) exhibited a stronger apoptotic effect in HT-29 cells than intact chrysin. The apoptotic characteristics induced by CM1 in HT-29 cells was mediated through the intrinsic signaling pathway, including the excessive production of included reactive oxygen species, the dissipation of the mitochondrial membrane potential, regulation of the B cell lymphoma-2 family, activation of caspase-9, 3, and cleavage of poly (adenosine diphosphate-ribose) polymerase. Our findings suggest that CM1 can be a potential anticancer candidate for the treatment of colon cancer.

Original language	English
Pages (from-to)	713-721
Number of pages	9
Journal	Journal of Medicinal Food
Volume	22
Issue number	7
DOIs	https://doi.org/10.1089/jmf.2018.4320
Publication status	Published - 2019 Jul

Keywords

apoptosis
chrysin derivative
colon cancer
gamma irradiation
reactive oxygen species

ASJC Scopus subject areas

Medicine (miscellaneous)
Nutrition and Dietetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1089/jmf.2018.4320

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title = "Gamma-irradiated chrysin improves anticancer activity in HT-29 colon cancer cells through mitochondria-related pathway",

abstract = "Irradiation technology can improve the biological activities of natural molecules through a structural modification. This study was conducted to investigate the enhancement of the anticancer effects of chrysin upon exposure to gamma irradiation. Gamma irradiation induces the production of new radiolytic peaks simultaneously with the decrease of the chrysin peak, which increases the cytotoxicity in HT-29 human colon cancer cells. An isolated chrysin derivative (CM1) exhibited a stronger apoptotic effect in HT-29 cells than intact chrysin. The apoptotic characteristics induced by CM1 in HT-29 cells was mediated through the intrinsic signaling pathway, including the excessive production of included reactive oxygen species, the dissipation of the mitochondrial membrane potential, regulation of the B cell lymphoma-2 family, activation of caspase-9, 3, and cleavage of poly (adenosine diphosphate-ribose) polymerase. Our findings suggest that CM1 can be a potential anticancer candidate for the treatment of colon cancer.",

keywords = "apoptosis, chrysin derivative, colon cancer, gamma irradiation, reactive oxygen species",

author = "Song, {Ha Yeon} and Kim, {Hye Min} and Sajid Mushtaq and Kim, {Woo Sik} and Kim, {Young Jun} and Lim, {Seung Taik} and Byun, {Eui Baek}",

note = "Funding Information: This study was supported by a Nuclear Research and Development Program of the National Research Foundation (NRF-2012M2A2A6011335) grant funded by the Government of the Republic of Korea. This study was also supported by Nuclear R&D Program of the Ministry of Science and ICT (MIST). Publisher Copyright: {\textcopyright} Copyright 2019, Mary Ann Liebert, Inc., publishers, and Korean Society of Food Science and Nutrition 2019.",

year = "2019",

month = jul,

doi = "10.1089/jmf.2018.4320",

language = "English",

volume = "22",

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journal = "Journal of Medicinal Food",

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T1 - Gamma-irradiated chrysin improves anticancer activity in HT-29 colon cancer cells through mitochondria-related pathway

AU - Song, Ha Yeon

AU - Kim, Hye Min

AU - Mushtaq, Sajid

AU - Kim, Woo Sik

AU - Kim, Young Jun

AU - Lim, Seung Taik

AU - Byun, Eui Baek

N1 - Funding Information: This study was supported by a Nuclear Research and Development Program of the National Research Foundation (NRF-2012M2A2A6011335) grant funded by the Government of the Republic of Korea. This study was also supported by Nuclear R&D Program of the Ministry of Science and ICT (MIST). Publisher Copyright: © Copyright 2019, Mary Ann Liebert, Inc., publishers, and Korean Society of Food Science and Nutrition 2019.

PY - 2019/7

Y1 - 2019/7

N2 - Irradiation technology can improve the biological activities of natural molecules through a structural modification. This study was conducted to investigate the enhancement of the anticancer effects of chrysin upon exposure to gamma irradiation. Gamma irradiation induces the production of new radiolytic peaks simultaneously with the decrease of the chrysin peak, which increases the cytotoxicity in HT-29 human colon cancer cells. An isolated chrysin derivative (CM1) exhibited a stronger apoptotic effect in HT-29 cells than intact chrysin. The apoptotic characteristics induced by CM1 in HT-29 cells was mediated through the intrinsic signaling pathway, including the excessive production of included reactive oxygen species, the dissipation of the mitochondrial membrane potential, regulation of the B cell lymphoma-2 family, activation of caspase-9, 3, and cleavage of poly (adenosine diphosphate-ribose) polymerase. Our findings suggest that CM1 can be a potential anticancer candidate for the treatment of colon cancer.

AB - Irradiation technology can improve the biological activities of natural molecules through a structural modification. This study was conducted to investigate the enhancement of the anticancer effects of chrysin upon exposure to gamma irradiation. Gamma irradiation induces the production of new radiolytic peaks simultaneously with the decrease of the chrysin peak, which increases the cytotoxicity in HT-29 human colon cancer cells. An isolated chrysin derivative (CM1) exhibited a stronger apoptotic effect in HT-29 cells than intact chrysin. The apoptotic characteristics induced by CM1 in HT-29 cells was mediated through the intrinsic signaling pathway, including the excessive production of included reactive oxygen species, the dissipation of the mitochondrial membrane potential, regulation of the B cell lymphoma-2 family, activation of caspase-9, 3, and cleavage of poly (adenosine diphosphate-ribose) polymerase. Our findings suggest that CM1 can be a potential anticancer candidate for the treatment of colon cancer.

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Gamma-irradiated chrysin improves anticancer activity in HT-29 colon cancer cells through mitochondria-related pathway

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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