Gamma knife stereotactic radiosurgery for drug resistant or intolerant invasive prolactinomas

Xiaomin Liu, Hideyuki Kano, Douglas Kondziolka, Kyung Jae Park, Aditya Iyer, Samuel Shin, Ajay Niranjan, John C. Flickinger, L. Dade Lunsford

    Research output: Contribution to journalArticlepeer-review

    31 Citations (Scopus)

    Abstract

    We evaluated the efficacy of Gamma knife stereotactic radiosurgery (GKSR) as an adjunctive management modality for patients with drug resistant or intolerant cavernous sinus invasive prolactinomas. Twenty-two patients with cavernous sinus invasive prolactinoma underwent GKSR between 1994 and 2009. Thirteen patients were dopamine agonist (DA) resistant. Six patients were intolerant to DA. Three patients chose GKSR as their initial treatment modality in hopes they might avoid life long suppression medication. The median tumor volume was 3.0 cm3 (range 0.3-11.6). The marginal tumor dose (median = 15 Gy, range 12-25 Gy) prescribed was based on the dose delivered to the optic apparatus. The median follow-up interval was 36 months (range, 12-185). Endocrine normalization was defined as a normal serum prolactin level off DA (cure) or on DA. Endocrine improvement was defined as a decreased but still elevated serum prolactin level. Endocrine deterioration was defined as an increased serum prolactin level. Endocrine normalization was achieved in six (27.3%) patients. Twelve (54.5%) patients had endocrine improvement. Four patients (18.2%) developed delayed increased prolactin. Imaging-defined local tumor control was achieved in 19 (86.4%) patients, 12 of whom had tumor regression. Three patients had a delayed tumor progression and required additional management. One patient developed a new pituitary axis deficiency after GKSR. Invasive prolactinomas continue to pose management challenges. GKSR is a non invasive adjunctive option that may reduce prolactin levels in patients who are resistant to or intolerant of suppression medication. In a minority of cases, patients may no longer require long term suppression therapy.

    Original languageEnglish
    Pages (from-to)68-75
    Number of pages8
    JournalPituitary
    Volume16
    Issue number1
    DOIs
    Publication statusPublished - 2013 Mar

    Keywords

    • Cavernous sinus
    • Gamma knife
    • Pituitary adenoma
    • Prolactinoma
    • Radiosurgery

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Endocrinology

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