Gastric acid secretion and gastrin release during continuous vagal neuromonitoring in thyroid surgery

Liu Xiaoli, Che Wei Wu, Hoon Yub Kim, Wen Tian, Feng Yu Chiang, Renbin Liu, Angkoon Anuwong, Gregory W. Randolph, Gianlorenzo Dionigi, Matteo Lavazza

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: The vagus nerve (VN) has essential regulatory roles in the gastric acid secretion and gastrin release. Continuous intraoperative neuromonitoring (CIONM) via VN stimulation is a promising technique in thyroid surgery because it potentially avoids injury to the recurrent laryngeal nerve. However, no studies have investigated changes in gastric acid secretion and gastrin release during CIONM. Method: This prospective study of 58 thyroid surgery patients compared gastric acid and serum gastrin at five time points: (1) before skin incision, (2) after baseline calibration of CIONM probe, (3) +20 min from baseline, (4) before probe removal, and (5) after extubation. Patients were excluded if they had any history of using tobacco, acid suppression medications, or drugs that affect gastric motility. Patients were also excluded if they had any history of gastroesophageal reflux symptoms, gastroesophageal reflux disease, peptic ulcer disease, helicobacter pylori infection, or chronic kidney disease. Results: Non significant differences in mean gastric pH values were observed at all time points, i.e., (1) before skin incision (2.2 ± 0.2; p = 0.50), (2) after baseline calibration of CIONM probe (2.0 ± 0.8; p = 0.62), (3) +20 min from baseline (2.5 ± 0.5; p = 0.24), (4) before probe removal (2.9 ± 0.9; p = 0.52), and (5) after extubation (2.6 ± 1.0; p = 0.60). Comparisons of pH monitoring parameters revealed no significant differences in age, gender, side of CIONM (left vs. right), sequence of CIONM, or duration of CIONM. Gastrin values were normal in sequential determinations and did not significantly differ at any time points. Conclusions: CIONM performed via VN stimulation during total thyroidectomy in healthy patients does not influence gastrin secretion and gastric pH.

Original languageEnglish
Pages (from-to)265-272
Number of pages8
JournalLangenbeck's Archives of Surgery
Volume402
Issue number2
DOIs
Publication statusPublished - 2017 Mar 1

Fingerprint

Gastric Acid
Gastrins
Thyroid Gland
Vagus Nerve Stimulation
Gastroesophageal Reflux
Calibration
Stomach
Recurrent Laryngeal Nerve Injuries
Gastrointestinal Agents
Skin
Vagus Nerve
Thyroidectomy
Helicobacter Infections
Peptic Ulcer
Chronic Renal Insufficiency
Helicobacter pylori
Tobacco
Reference Values
Prospective Studies
Acids

Keywords

  • C-IONM
  • Gastric acid
  • Gastrin release
  • Thyroid surgery
  • Vagal nerve

ASJC Scopus subject areas

  • Surgery

Cite this

Gastric acid secretion and gastrin release during continuous vagal neuromonitoring in thyroid surgery. / Xiaoli, Liu; Wu, Che Wei; Kim, Hoon Yub; Tian, Wen; Chiang, Feng Yu; Liu, Renbin; Anuwong, Angkoon; Randolph, Gregory W.; Dionigi, Gianlorenzo; Lavazza, Matteo.

In: Langenbeck's Archives of Surgery, Vol. 402, No. 2, 01.03.2017, p. 265-272.

Research output: Contribution to journalArticle

Xiaoli, L, Wu, CW, Kim, HY, Tian, W, Chiang, FY, Liu, R, Anuwong, A, Randolph, GW, Dionigi, G & Lavazza, M 2017, 'Gastric acid secretion and gastrin release during continuous vagal neuromonitoring in thyroid surgery', Langenbeck's Archives of Surgery, vol. 402, no. 2, pp. 265-272. https://doi.org/10.1007/s00423-017-1555-z
Xiaoli, Liu ; Wu, Che Wei ; Kim, Hoon Yub ; Tian, Wen ; Chiang, Feng Yu ; Liu, Renbin ; Anuwong, Angkoon ; Randolph, Gregory W. ; Dionigi, Gianlorenzo ; Lavazza, Matteo. / Gastric acid secretion and gastrin release during continuous vagal neuromonitoring in thyroid surgery. In: Langenbeck's Archives of Surgery. 2017 ; Vol. 402, No. 2. pp. 265-272.
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abstract = "Purpose: The vagus nerve (VN) has essential regulatory roles in the gastric acid secretion and gastrin release. Continuous intraoperative neuromonitoring (CIONM) via VN stimulation is a promising technique in thyroid surgery because it potentially avoids injury to the recurrent laryngeal nerve. However, no studies have investigated changes in gastric acid secretion and gastrin release during CIONM. Method: This prospective study of 58 thyroid surgery patients compared gastric acid and serum gastrin at five time points: (1) before skin incision, (2) after baseline calibration of CIONM probe, (3) +20 min from baseline, (4) before probe removal, and (5) after extubation. Patients were excluded if they had any history of using tobacco, acid suppression medications, or drugs that affect gastric motility. Patients were also excluded if they had any history of gastroesophageal reflux symptoms, gastroesophageal reflux disease, peptic ulcer disease, helicobacter pylori infection, or chronic kidney disease. Results: Non significant differences in mean gastric pH values were observed at all time points, i.e., (1) before skin incision (2.2 ± 0.2; p = 0.50), (2) after baseline calibration of CIONM probe (2.0 ± 0.8; p = 0.62), (3) +20 min from baseline (2.5 ± 0.5; p = 0.24), (4) before probe removal (2.9 ± 0.9; p = 0.52), and (5) after extubation (2.6 ± 1.0; p = 0.60). Comparisons of pH monitoring parameters revealed no significant differences in age, gender, side of CIONM (left vs. right), sequence of CIONM, or duration of CIONM. Gastrin values were normal in sequential determinations and did not significantly differ at any time points. Conclusions: CIONM performed via VN stimulation during total thyroidectomy in healthy patients does not influence gastrin secretion and gastric pH.",
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