Gastric lesions in patients with Crohn's disease in Korea: A multicenter study

Korean Association for the Study of Intestinal Diseases

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background/Aims: Gastric pathology and Helicobacter pylori (H. pylori ) infection among Asian patients with Crohn's disease (CD) are still unclear. We evaluated gastric histologic features and frequency of H. pylori infection in Korean patients with CD. Methods: Among 492 patients with CD receiving upper gastrointestinal (GI) endoscopic evaluation in 19 Korean hospitals, we evaluated the endoscopic findings and gastric histopathologic features of 47 patients for our study. Histopathologic classification was performed using gastric biopsy tissues, and H. pylori infection was determined using the rapid urease test and histology. Results: There were 36 men (76.6%), and the median age of patients at the time of upper GI endoscopy was 23.8 years (range, 14.2-60.5). For CD phenotype, ileocolonic disease was observed in 38 patients (80.9%), and non-stricturing, nonpenetrating disease in 31 patients (66.0%). Twenty-eight patients (59.6%) complained of upper GI symptoms. Erosive gastritis was the most common gross gastric feature (66.0%). Histopathologically, H. pylori -negative chronic active gastritis (38.3%) was the most frequent finding. H. pylori testing was positive in 11 patients (23.4%), and gastric noncaseating granulomata were detected in 4 patients (8.5%). Gastric noncaseating granuloma showed a statistically significant association with perianal abscess/ fistula (P =0.0496). Conclusions: H. pylori -negative chronic active gastritis appears to be frequent among Korean patients with CD. The frequency of H. pylori infection was comparable with previous studies. An association with perianal complications suggests a prognostic value for gastric noncaseating granuloma in patients with CD.

Original languageEnglish
Pages (from-to)60-68
Number of pages9
JournalIntestinal Research
Volume14
Issue number1
DOIs
Publication statusPublished - 2016 Jan 1

Fingerprint

Korea
Crohn Disease
Multicenter Studies
Stomach
Helicobacter pylori
Helicobacter Infections
Gastritis
Granuloma
Gastrointestinal Endoscopy
Urease
Abscess
Fistula
Histology
Pathology
Phenotype
Biopsy

Keywords

  • Crohn disease
  • Gastritis
  • Granuloma
  • Helicobacter pylori
  • Stomach

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Gastric lesions in patients with Crohn's disease in Korea : A multicenter study. / Korean Association for the Study of Intestinal Diseases.

In: Intestinal Research, Vol. 14, No. 1, 01.01.2016, p. 60-68.

Research output: Contribution to journalArticle

Korean Association for the Study of Intestinal Diseases 2016, 'Gastric lesions in patients with Crohn's disease in Korea: A multicenter study', Intestinal Research, vol. 14, no. 1, pp. 60-68. https://doi.org/10.5217/ir.2016.14.1.60
Korean Association for the Study of Intestinal Diseases. / Gastric lesions in patients with Crohn's disease in Korea : A multicenter study. In: Intestinal Research. 2016 ; Vol. 14, No. 1. pp. 60-68.
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abstract = "Background/Aims: Gastric pathology and Helicobacter pylori (H. pylori ) infection among Asian patients with Crohn's disease (CD) are still unclear. We evaluated gastric histologic features and frequency of H. pylori infection in Korean patients with CD. Methods: Among 492 patients with CD receiving upper gastrointestinal (GI) endoscopic evaluation in 19 Korean hospitals, we evaluated the endoscopic findings and gastric histopathologic features of 47 patients for our study. Histopathologic classification was performed using gastric biopsy tissues, and H. pylori infection was determined using the rapid urease test and histology. Results: There were 36 men (76.6{\%}), and the median age of patients at the time of upper GI endoscopy was 23.8 years (range, 14.2-60.5). For CD phenotype, ileocolonic disease was observed in 38 patients (80.9{\%}), and non-stricturing, nonpenetrating disease in 31 patients (66.0{\%}). Twenty-eight patients (59.6{\%}) complained of upper GI symptoms. Erosive gastritis was the most common gross gastric feature (66.0{\%}). Histopathologically, H. pylori -negative chronic active gastritis (38.3{\%}) was the most frequent finding. H. pylori testing was positive in 11 patients (23.4{\%}), and gastric noncaseating granulomata were detected in 4 patients (8.5{\%}). Gastric noncaseating granuloma showed a statistically significant association with perianal abscess/ fistula (P =0.0496). Conclusions: H. pylori -negative chronic active gastritis appears to be frequent among Korean patients with CD. The frequency of H. pylori infection was comparable with previous studies. An association with perianal complications suggests a prognostic value for gastric noncaseating granuloma in patients with CD.",
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AU - Park, Young Soo

AU - Kim, Jihun

AU - Kim, Joo Sung

AU - Moon, Won

AU - Lee, Kang Moon

AU - Kim, You Sun

AU - Keum, Bora

AU - Kim, Seong Eun

AU - Kim, Kyeong Ok

AU - Kim, Eun Soo

AU - Lee, Chang Kyun

AU - Hong, Sung Pil

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AU - Koo, Ja Seol

AU - Choi, Chang Hwan

AU - Shin, Jeong Eun

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KW - Crohn disease

KW - Gastritis

KW - Granuloma

KW - Helicobacter pylori

KW - Stomach

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