Gastroprotective effect of cyanidin 3-glucoside on ethanol-induced gastric lesions in rats

Chun Ying Li, Hong De Xu, Bing Tian Zhao, Hyo Ihl Chang, Hae Ik Rhee

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

This study investigated the in vivo protective effect of cyanidin 3-glucoside (C3G) against ethanol-induced gastric lesions in rats. The experimental rats were treated with 80% ethanol after pretreatment with various doses of C3G (4 and 8 mg/kg of body weight), and the control rats received only 80% ethanol. Oral pretreatment with C3G significantly inhibited the formation of ethanol-induced gastric lesions and the elevation of the lipid peroxide level. In addition, pretreatment with C3G significantly increased the level of glutathione and the activities of radical scavenging enzymes, such as superoxide dismutase, catalase, and glutathione peroxidase, in gastric tissues. These results suggest that the gastroprotective effect of C3G removes the ethanol-induced lipid peroxides and free radicals and that it may offer a potential remedy for the treatment of gastric lesions.

Original languageEnglish
Pages (from-to)683-687
Number of pages5
JournalAlcohol
Volume42
Issue number8
DOIs
Publication statusPublished - 2008 Dec

Keywords

  • Antioxidant
  • Cyanidin 3-glucoside
  • Gastric lesion

ASJC Scopus subject areas

  • Health(social science)
  • Biochemistry
  • Toxicology
  • Neurology
  • Behavioral Neuroscience

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