Gender- and cholesterol-specific predictive value of body mass index in renal cell carcinoma: A multicenter study

Hyun Cheol Jeong, Fahad K. Bashraheel, Seok Soo Byun, Cheol Kwak, Eu Chang Hwang, Seok Ho Kang, Jinsoo Chung, Tae Hwan Kim, Yong June Kim, Sung Hoo Hong

Research output: Contribution to journalArticle

Abstract

Aim: Recently, there have been some reports on preoperative body mass index (BMI) and total cholesterol (TC) as a prognostic predictor for patients with renal cell carcinoma (RCC) but the topic is controversial and still poorly understood. So we analyzed the effects of BMI and TC on the prognosis of RCC. Methods: Retrospective data from 1988 to 2015 were collected from eight centers with a total of 7,271 patients surgically treated for nonmetastatic RCC. Receiver operating characteristic curve analysis was analyzed and the highest Youden index was shown at 163.5 mg/dL. According to the Asian BMI criteria, patients were divided into normal BMI < 25 kg/m2 and high BMI ≥ 25 kg/m2. Kaplan-Meier analysis, multivariate Cox regression model were performed to identify the overall survival (OS) and the recurrence-free survival (RFS). Results: Normal BMI and low TC group was associated with the shortest OS and RFS as compared to the other groups significantly. In the male patients, the results showed similar to the whole sample. But in the female, BMI had no effect on both OS and RFS. On multivariate Cox regression analysis, low TC was an independent predictor for OS in both genders. However, normal BMI was a significant prognostic factor in the males only. Conclusion: Preoperative BMI and TC are good predictive factors for both OS and RFS significantly in RCC patients. Also, TC was an independent predictor for OS in all RCC patients; however, BMI was a significant predictor in males only.

Original languageEnglish
JournalAsia-Pacific Journal of Clinical Oncology
DOIs
Publication statusAccepted/In press - 2018 Jan 1

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Renal Cell Carcinoma
Multicenter Studies
Body Mass Index
Cholesterol
Survival
Recurrence
Kaplan-Meier Estimate
Proportional Hazards Models
ROC Curve
Regression Analysis

Keywords

  • body mass index
  • cholesterol
  • gender
  • multicenter study
  • predictive value
  • renal cell carcinoma

ASJC Scopus subject areas

  • Oncology

Cite this

Gender- and cholesterol-specific predictive value of body mass index in renal cell carcinoma : A multicenter study. / Jeong, Hyun Cheol; Bashraheel, Fahad K.; Byun, Seok Soo; Kwak, Cheol; Hwang, Eu Chang; Kang, Seok Ho; Chung, Jinsoo; Kim, Tae Hwan; Kim, Yong June; Hong, Sung Hoo.

In: Asia-Pacific Journal of Clinical Oncology, 01.01.2018.

Research output: Contribution to journalArticle

Jeong, Hyun Cheol ; Bashraheel, Fahad K. ; Byun, Seok Soo ; Kwak, Cheol ; Hwang, Eu Chang ; Kang, Seok Ho ; Chung, Jinsoo ; Kim, Tae Hwan ; Kim, Yong June ; Hong, Sung Hoo. / Gender- and cholesterol-specific predictive value of body mass index in renal cell carcinoma : A multicenter study. In: Asia-Pacific Journal of Clinical Oncology. 2018.
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abstract = "Aim: Recently, there have been some reports on preoperative body mass index (BMI) and total cholesterol (TC) as a prognostic predictor for patients with renal cell carcinoma (RCC) but the topic is controversial and still poorly understood. So we analyzed the effects of BMI and TC on the prognosis of RCC. Methods: Retrospective data from 1988 to 2015 were collected from eight centers with a total of 7,271 patients surgically treated for nonmetastatic RCC. Receiver operating characteristic curve analysis was analyzed and the highest Youden index was shown at 163.5 mg/dL. According to the Asian BMI criteria, patients were divided into normal BMI < 25 kg/m2 and high BMI ≥ 25 kg/m2. Kaplan-Meier analysis, multivariate Cox regression model were performed to identify the overall survival (OS) and the recurrence-free survival (RFS). Results: Normal BMI and low TC group was associated with the shortest OS and RFS as compared to the other groups significantly. In the male patients, the results showed similar to the whole sample. But in the female, BMI had no effect on both OS and RFS. On multivariate Cox regression analysis, low TC was an independent predictor for OS in both genders. However, normal BMI was a significant prognostic factor in the males only. Conclusion: Preoperative BMI and TC are good predictive factors for both OS and RFS significantly in RCC patients. Also, TC was an independent predictor for OS in all RCC patients; however, BMI was a significant predictor in males only.",
keywords = "body mass index, cholesterol, gender, multicenter study, predictive value, renal cell carcinoma",
author = "Jeong, {Hyun Cheol} and Bashraheel, {Fahad K.} and Byun, {Seok Soo} and Cheol Kwak and Hwang, {Eu Chang} and Kang, {Seok Ho} and Jinsoo Chung and Kim, {Tae Hwan} and Kim, {Yong June} and Hong, {Sung Hoo}",
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AU - Jeong, Hyun Cheol

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AU - Byun, Seok Soo

AU - Kwak, Cheol

AU - Hwang, Eu Chang

AU - Kang, Seok Ho

AU - Chung, Jinsoo

AU - Kim, Tae Hwan

AU - Kim, Yong June

AU - Hong, Sung Hoo

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N2 - Aim: Recently, there have been some reports on preoperative body mass index (BMI) and total cholesterol (TC) as a prognostic predictor for patients with renal cell carcinoma (RCC) but the topic is controversial and still poorly understood. So we analyzed the effects of BMI and TC on the prognosis of RCC. Methods: Retrospective data from 1988 to 2015 were collected from eight centers with a total of 7,271 patients surgically treated for nonmetastatic RCC. Receiver operating characteristic curve analysis was analyzed and the highest Youden index was shown at 163.5 mg/dL. According to the Asian BMI criteria, patients were divided into normal BMI < 25 kg/m2 and high BMI ≥ 25 kg/m2. Kaplan-Meier analysis, multivariate Cox regression model were performed to identify the overall survival (OS) and the recurrence-free survival (RFS). Results: Normal BMI and low TC group was associated with the shortest OS and RFS as compared to the other groups significantly. In the male patients, the results showed similar to the whole sample. But in the female, BMI had no effect on both OS and RFS. On multivariate Cox regression analysis, low TC was an independent predictor for OS in both genders. However, normal BMI was a significant prognostic factor in the males only. Conclusion: Preoperative BMI and TC are good predictive factors for both OS and RFS significantly in RCC patients. Also, TC was an independent predictor for OS in all RCC patients; however, BMI was a significant predictor in males only.

AB - Aim: Recently, there have been some reports on preoperative body mass index (BMI) and total cholesterol (TC) as a prognostic predictor for patients with renal cell carcinoma (RCC) but the topic is controversial and still poorly understood. So we analyzed the effects of BMI and TC on the prognosis of RCC. Methods: Retrospective data from 1988 to 2015 were collected from eight centers with a total of 7,271 patients surgically treated for nonmetastatic RCC. Receiver operating characteristic curve analysis was analyzed and the highest Youden index was shown at 163.5 mg/dL. According to the Asian BMI criteria, patients were divided into normal BMI < 25 kg/m2 and high BMI ≥ 25 kg/m2. Kaplan-Meier analysis, multivariate Cox regression model were performed to identify the overall survival (OS) and the recurrence-free survival (RFS). Results: Normal BMI and low TC group was associated with the shortest OS and RFS as compared to the other groups significantly. In the male patients, the results showed similar to the whole sample. But in the female, BMI had no effect on both OS and RFS. On multivariate Cox regression analysis, low TC was an independent predictor for OS in both genders. However, normal BMI was a significant prognostic factor in the males only. Conclusion: Preoperative BMI and TC are good predictive factors for both OS and RFS significantly in RCC patients. Also, TC was an independent predictor for OS in all RCC patients; however, BMI was a significant predictor in males only.

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