Gender differences in 12-week antidepressant treatment outcomes for a naturalistic secondary care cohort: The CRESCEND study

Su Jin Yang, Sun Young Kim, Robert Stewart, Jae Min Kim, Il Seon Shin, Sung Won Jung, Min-Soo Lee, Seung Hee Jeong, Tae Youn Jun

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

This study aimed to determine whether men and women with depression differ in socio-demographic, treatment-related characteristics, and in their responses to treatment with antidepressants, as well as to explore differences in treatment outcomes by menopausal status. From a nationwide sample of 18 hospitals in South Korea, 723 depressive patients were recruited. After baseline evaluation, they received naturalistic clinician-determined antidepressant interventions. Assessment scales for evaluating depression (HAMD), anxiety (HAMA), global severity (CGI-s), and functioning (SOFAS) were administered at baseline and re-evaluated at 1, 2, 4, 8, and 12 weeks later. At baseline, women were older, less educated, less likely to be employed, had lower income, were more likely to be married, and had longer illness duration than men. There were no gender differences in the treatment-regime received. After adjustment for baseline status, women were more likely to achieve HAMD remission (OR = 1.51), HAMD response (OR = 1.64), and HAMA response (OR = 1.61). Women also experienced shorter times to HAMD response, HAMA response, and CGI-s remission. Postmenopausal women showed higher HAMA response with newer dual action antidepressants than premenopausal women. Women were found to have better outcomes following antidepressant treatment than men, and postmenopausal women had a better response on anxiety symptoms with newer dual action antidepressants.

Original languageEnglish
Pages (from-to)82-90
Number of pages9
JournalPsychiatry Research
Volume189
Issue number1
DOIs
Publication statusPublished - 2011 Aug 30

Fingerprint

Secondary Care
Antidepressive Agents
Anxiety
Depression
Republic of Korea
Women's Rights
Therapeutics
Demography

Keywords

  • Antidepressants
  • Depression
  • Gender differences
  • Korea
  • Treatment outcome

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Gender differences in 12-week antidepressant treatment outcomes for a naturalistic secondary care cohort : The CRESCEND study. / Yang, Su Jin; Kim, Sun Young; Stewart, Robert; Kim, Jae Min; Shin, Il Seon; Jung, Sung Won; Lee, Min-Soo; Jeong, Seung Hee; Jun, Tae Youn.

In: Psychiatry Research, Vol. 189, No. 1, 30.08.2011, p. 82-90.

Research output: Contribution to journalArticle

Yang, SJ, Kim, SY, Stewart, R, Kim, JM, Shin, IS, Jung, SW, Lee, M-S, Jeong, SH & Jun, TY 2011, 'Gender differences in 12-week antidepressant treatment outcomes for a naturalistic secondary care cohort: The CRESCEND study', Psychiatry Research, vol. 189, no. 1, pp. 82-90. https://doi.org/10.1016/j.psychres.2010.12.027
Yang, Su Jin ; Kim, Sun Young ; Stewart, Robert ; Kim, Jae Min ; Shin, Il Seon ; Jung, Sung Won ; Lee, Min-Soo ; Jeong, Seung Hee ; Jun, Tae Youn. / Gender differences in 12-week antidepressant treatment outcomes for a naturalistic secondary care cohort : The CRESCEND study. In: Psychiatry Research. 2011 ; Vol. 189, No. 1. pp. 82-90.
@article{e336ab4bbc24484d8739043ee2b10d37,
title = "Gender differences in 12-week antidepressant treatment outcomes for a naturalistic secondary care cohort: The CRESCEND study",
abstract = "This study aimed to determine whether men and women with depression differ in socio-demographic, treatment-related characteristics, and in their responses to treatment with antidepressants, as well as to explore differences in treatment outcomes by menopausal status. From a nationwide sample of 18 hospitals in South Korea, 723 depressive patients were recruited. After baseline evaluation, they received naturalistic clinician-determined antidepressant interventions. Assessment scales for evaluating depression (HAMD), anxiety (HAMA), global severity (CGI-s), and functioning (SOFAS) were administered at baseline and re-evaluated at 1, 2, 4, 8, and 12 weeks later. At baseline, women were older, less educated, less likely to be employed, had lower income, were more likely to be married, and had longer illness duration than men. There were no gender differences in the treatment-regime received. After adjustment for baseline status, women were more likely to achieve HAMD remission (OR = 1.51), HAMD response (OR = 1.64), and HAMA response (OR = 1.61). Women also experienced shorter times to HAMD response, HAMA response, and CGI-s remission. Postmenopausal women showed higher HAMA response with newer dual action antidepressants than premenopausal women. Women were found to have better outcomes following antidepressant treatment than men, and postmenopausal women had a better response on anxiety symptoms with newer dual action antidepressants.",
keywords = "Antidepressants, Depression, Gender differences, Korea, Treatment outcome",
author = "Yang, {Su Jin} and Kim, {Sun Young} and Robert Stewart and Kim, {Jae Min} and Shin, {Il Seon} and Jung, {Sung Won} and Min-Soo Lee and Jeong, {Seung Hee} and Jun, {Tae Youn}",
year = "2011",
month = "8",
day = "30",
doi = "10.1016/j.psychres.2010.12.027",
language = "English",
volume = "189",
pages = "82--90",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Gender differences in 12-week antidepressant treatment outcomes for a naturalistic secondary care cohort

T2 - The CRESCEND study

AU - Yang, Su Jin

AU - Kim, Sun Young

AU - Stewart, Robert

AU - Kim, Jae Min

AU - Shin, Il Seon

AU - Jung, Sung Won

AU - Lee, Min-Soo

AU - Jeong, Seung Hee

AU - Jun, Tae Youn

PY - 2011/8/30

Y1 - 2011/8/30

N2 - This study aimed to determine whether men and women with depression differ in socio-demographic, treatment-related characteristics, and in their responses to treatment with antidepressants, as well as to explore differences in treatment outcomes by menopausal status. From a nationwide sample of 18 hospitals in South Korea, 723 depressive patients were recruited. After baseline evaluation, they received naturalistic clinician-determined antidepressant interventions. Assessment scales for evaluating depression (HAMD), anxiety (HAMA), global severity (CGI-s), and functioning (SOFAS) were administered at baseline and re-evaluated at 1, 2, 4, 8, and 12 weeks later. At baseline, women were older, less educated, less likely to be employed, had lower income, were more likely to be married, and had longer illness duration than men. There were no gender differences in the treatment-regime received. After adjustment for baseline status, women were more likely to achieve HAMD remission (OR = 1.51), HAMD response (OR = 1.64), and HAMA response (OR = 1.61). Women also experienced shorter times to HAMD response, HAMA response, and CGI-s remission. Postmenopausal women showed higher HAMA response with newer dual action antidepressants than premenopausal women. Women were found to have better outcomes following antidepressant treatment than men, and postmenopausal women had a better response on anxiety symptoms with newer dual action antidepressants.

AB - This study aimed to determine whether men and women with depression differ in socio-demographic, treatment-related characteristics, and in their responses to treatment with antidepressants, as well as to explore differences in treatment outcomes by menopausal status. From a nationwide sample of 18 hospitals in South Korea, 723 depressive patients were recruited. After baseline evaluation, they received naturalistic clinician-determined antidepressant interventions. Assessment scales for evaluating depression (HAMD), anxiety (HAMA), global severity (CGI-s), and functioning (SOFAS) were administered at baseline and re-evaluated at 1, 2, 4, 8, and 12 weeks later. At baseline, women were older, less educated, less likely to be employed, had lower income, were more likely to be married, and had longer illness duration than men. There were no gender differences in the treatment-regime received. After adjustment for baseline status, women were more likely to achieve HAMD remission (OR = 1.51), HAMD response (OR = 1.64), and HAMA response (OR = 1.61). Women also experienced shorter times to HAMD response, HAMA response, and CGI-s remission. Postmenopausal women showed higher HAMA response with newer dual action antidepressants than premenopausal women. Women were found to have better outcomes following antidepressant treatment than men, and postmenopausal women had a better response on anxiety symptoms with newer dual action antidepressants.

KW - Antidepressants

KW - Depression

KW - Gender differences

KW - Korea

KW - Treatment outcome

UR - http://www.scopus.com/inward/record.url?scp=79958096715&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79958096715&partnerID=8YFLogxK

U2 - 10.1016/j.psychres.2010.12.027

DO - 10.1016/j.psychres.2010.12.027

M3 - Article

C2 - 21216471

AN - SCOPUS:79958096715

VL - 189

SP - 82

EP - 90

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

IS - 1

ER -