Gender Differences in Endovascular Revascularization for Peripheral Arterial Disease

Michael S. Lee, Seung-Woon Rha, Seung-Kyu Han, Byoung Geol Choi, Se Yeon Choi, Pejman Mansourian, Jabar Ali, Shaopeng Xu, Harris Abdullah Ngow, Gwang No Lee, Jae Joong Lee, Ji Bak Kim, Sunki Lee, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Jin Won Kim, Eung Ju Kim, Chang Gyu Park, Hong Seog SeoDong Joo Oh

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: Peripheral arterial disease (PAD) can be treated with percutaneous transluminal angioplasty (PTA). Data comparing the outcomes of females to males with PAD who undergo PTA is limited. We compared the clinical outcomes of male and female patients with PAD who underwent PTA. Methods: In a singlecenter, prospective registry, the outcomes of 239 consecutive patients who underwent PTA for symptomatic PAD stratified by gender were analyzed. The primary endpoint was restenosis at 8 months. The secondary end points were repeat PTA, target lesion revascularization, target extremity revascularization, and amputation at a follow-up of 2 years. Results: Female patients were older (69.5±11.1 vs 65±11.6 years of age, P=.04) and had a trend toward a higher percentage of diabetic foot wound (58.1% vs 44.5%, P=.076) and PTA of tibial artery lesions (63.6% vs 53.8%, P=.064). Females had higher incidence of major hematoma (≥4 cm; 18.1% vs 8.1%, P=.033). No significant differences were observed between females and males for binary restenosis at 8 months and clinical events at 2 years. Conclusions: Female patients were older and had trends toward a higher percentage of diabetic foot wound as the initial diagnosis for PTA and PTA of tibial artery lesions. Despite having a higher incidence of major hematoma, females who underwent PTA had no significant differences in restenosis and 2-year clinical outcomes. PTA represents a viable treatment option for female patients with symptomatic PAD.

Original languageEnglish
Pages (from-to)117-125
Number of pages9
JournalVascular Disease Management
Volume12
Issue number7
Publication statusPublished - 2015 Jul 1

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Peripheral Arterial Disease
Angioplasty
Tibial Arteries
Diabetic Foot
Hematoma
Incidence
Wounds and Injuries
Amputation
Registries
Extremities

Keywords

  • Angioplasty
  • Endovascular therapy
  • Percutaneous transluminal angioplasty
  • Peripheral vascular disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Lee, M. S., Rha, S-W., Han, S-K., Choi, B. G., Choi, S. Y., Mansourian, P., ... Oh, D. J. (2015). Gender Differences in Endovascular Revascularization for Peripheral Arterial Disease. Vascular Disease Management, 12(7), 117-125.

Gender Differences in Endovascular Revascularization for Peripheral Arterial Disease. / Lee, Michael S.; Rha, Seung-Woon; Han, Seung-Kyu; Choi, Byoung Geol; Choi, Se Yeon; Mansourian, Pejman; Ali, Jabar; Xu, Shaopeng; Ngow, Harris Abdullah; Lee, Gwang No; Lee, Jae Joong; Kim, Ji Bak; Lee, Sunki; Na, Jin Oh; Choi, Cheol Ung; Lim, Hong Euy; Kim, Jin Won; Kim, Eung Ju; Park, Chang Gyu; Seo, Hong Seog; Oh, Dong Joo.

In: Vascular Disease Management, Vol. 12, No. 7, 01.07.2015, p. 117-125.

Research output: Contribution to journalArticle

Lee, MS, Rha, S-W, Han, S-K, Choi, BG, Choi, SY, Mansourian, P, Ali, J, Xu, S, Ngow, HA, Lee, GN, Lee, JJ, Kim, JB, Lee, S, Na, JO, Choi, CU, Lim, HE, Kim, JW, Kim, EJ, Park, CG, Seo, HS & Oh, DJ 2015, 'Gender Differences in Endovascular Revascularization for Peripheral Arterial Disease', Vascular Disease Management, vol. 12, no. 7, pp. 117-125.
Lee, Michael S. ; Rha, Seung-Woon ; Han, Seung-Kyu ; Choi, Byoung Geol ; Choi, Se Yeon ; Mansourian, Pejman ; Ali, Jabar ; Xu, Shaopeng ; Ngow, Harris Abdullah ; Lee, Gwang No ; Lee, Jae Joong ; Kim, Ji Bak ; Lee, Sunki ; Na, Jin Oh ; Choi, Cheol Ung ; Lim, Hong Euy ; Kim, Jin Won ; Kim, Eung Ju ; Park, Chang Gyu ; Seo, Hong Seog ; Oh, Dong Joo. / Gender Differences in Endovascular Revascularization for Peripheral Arterial Disease. In: Vascular Disease Management. 2015 ; Vol. 12, No. 7. pp. 117-125.
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abstract = "Objective: Peripheral arterial disease (PAD) can be treated with percutaneous transluminal angioplasty (PTA). Data comparing the outcomes of females to males with PAD who undergo PTA is limited. We compared the clinical outcomes of male and female patients with PAD who underwent PTA. Methods: In a singlecenter, prospective registry, the outcomes of 239 consecutive patients who underwent PTA for symptomatic PAD stratified by gender were analyzed. The primary endpoint was restenosis at 8 months. The secondary end points were repeat PTA, target lesion revascularization, target extremity revascularization, and amputation at a follow-up of 2 years. Results: Female patients were older (69.5±11.1 vs 65±11.6 years of age, P=.04) and had a trend toward a higher percentage of diabetic foot wound (58.1{\%} vs 44.5{\%}, P=.076) and PTA of tibial artery lesions (63.6{\%} vs 53.8{\%}, P=.064). Females had higher incidence of major hematoma (≥4 cm; 18.1{\%} vs 8.1{\%}, P=.033). No significant differences were observed between females and males for binary restenosis at 8 months and clinical events at 2 years. Conclusions: Female patients were older and had trends toward a higher percentage of diabetic foot wound as the initial diagnosis for PTA and PTA of tibial artery lesions. Despite having a higher incidence of major hematoma, females who underwent PTA had no significant differences in restenosis and 2-year clinical outcomes. PTA represents a viable treatment option for female patients with symptomatic PAD.",
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T1 - Gender Differences in Endovascular Revascularization for Peripheral Arterial Disease

AU - Lee, Michael S.

AU - Rha, Seung-Woon

AU - Han, Seung-Kyu

AU - Choi, Byoung Geol

AU - Choi, Se Yeon

AU - Mansourian, Pejman

AU - Ali, Jabar

AU - Xu, Shaopeng

AU - Ngow, Harris Abdullah

AU - Lee, Gwang No

AU - Lee, Jae Joong

AU - Kim, Ji Bak

AU - Lee, Sunki

AU - Na, Jin Oh

AU - Choi, Cheol Ung

AU - Lim, Hong Euy

AU - Kim, Jin Won

AU - Kim, Eung Ju

AU - Park, Chang Gyu

AU - Seo, Hong Seog

AU - Oh, Dong Joo

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Objective: Peripheral arterial disease (PAD) can be treated with percutaneous transluminal angioplasty (PTA). Data comparing the outcomes of females to males with PAD who undergo PTA is limited. We compared the clinical outcomes of male and female patients with PAD who underwent PTA. Methods: In a singlecenter, prospective registry, the outcomes of 239 consecutive patients who underwent PTA for symptomatic PAD stratified by gender were analyzed. The primary endpoint was restenosis at 8 months. The secondary end points were repeat PTA, target lesion revascularization, target extremity revascularization, and amputation at a follow-up of 2 years. Results: Female patients were older (69.5±11.1 vs 65±11.6 years of age, P=.04) and had a trend toward a higher percentage of diabetic foot wound (58.1% vs 44.5%, P=.076) and PTA of tibial artery lesions (63.6% vs 53.8%, P=.064). Females had higher incidence of major hematoma (≥4 cm; 18.1% vs 8.1%, P=.033). No significant differences were observed between females and males for binary restenosis at 8 months and clinical events at 2 years. Conclusions: Female patients were older and had trends toward a higher percentage of diabetic foot wound as the initial diagnosis for PTA and PTA of tibial artery lesions. Despite having a higher incidence of major hematoma, females who underwent PTA had no significant differences in restenosis and 2-year clinical outcomes. PTA represents a viable treatment option for female patients with symptomatic PAD.

AB - Objective: Peripheral arterial disease (PAD) can be treated with percutaneous transluminal angioplasty (PTA). Data comparing the outcomes of females to males with PAD who undergo PTA is limited. We compared the clinical outcomes of male and female patients with PAD who underwent PTA. Methods: In a singlecenter, prospective registry, the outcomes of 239 consecutive patients who underwent PTA for symptomatic PAD stratified by gender were analyzed. The primary endpoint was restenosis at 8 months. The secondary end points were repeat PTA, target lesion revascularization, target extremity revascularization, and amputation at a follow-up of 2 years. Results: Female patients were older (69.5±11.1 vs 65±11.6 years of age, P=.04) and had a trend toward a higher percentage of diabetic foot wound (58.1% vs 44.5%, P=.076) and PTA of tibial artery lesions (63.6% vs 53.8%, P=.064). Females had higher incidence of major hematoma (≥4 cm; 18.1% vs 8.1%, P=.033). No significant differences were observed between females and males for binary restenosis at 8 months and clinical events at 2 years. Conclusions: Female patients were older and had trends toward a higher percentage of diabetic foot wound as the initial diagnosis for PTA and PTA of tibial artery lesions. Despite having a higher incidence of major hematoma, females who underwent PTA had no significant differences in restenosis and 2-year clinical outcomes. PTA represents a viable treatment option for female patients with symptomatic PAD.

KW - Angioplasty

KW - Endovascular therapy

KW - Percutaneous transluminal angioplasty

KW - Peripheral vascular disease

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