Gender differences in the presentation of chest pain in obstructive coronary artery disease: Results from the korean women’s chest pain registry

Dong Hyuk Cho, Jimi Choi, Mi Na Kim, Hack Lyoung Kim, Yong Hyun Kim, Jin Oh Na, Jin Ok Jeong, Hyun Ju Yoon, Mi Seung Shin, Myung A. Kim, Kyung Soon Hong, Gil Ja Shin, Seong Mi Park, Wan Joo Shim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background/Aims: Chest pain in patients with obstructive coronary artery disease (OCAD) is affected by several social factors. The gender-based differences in chest pain among Koreans have yet to be investigated. Methods: The study consecutively enrolled 1,549 patients (male/female, 514/1,035; 61 ± 11 years old) with suspected angina. The predictive factors for OCAD based on gender were evaluated. Results: Men experienced more squeezing type pain on the left side of chest, while women demonstrated more dull quality pain in the retrosternal and epi-gastric area. After adjustment for risk factors, pain in the retrosternal area (odds ratio [OR], 1. 491; 95% confidence interval [CI], 1.178 to 1.887) and aggravation by exercise (OR, 2.235; 95% CI, 1.745 to 2.861) were positively associated with OCAD. In men, shorter duration (OR, 1.581; 95% CI, 1.086 to 2.303) and dyspnea (OR, 1.610; 95% CI, 1.040 to 2. 490) increased the probability for OCAD, while left-sid-ed chest pain suggested a low probability for OCAD (OR, 0.590; 95% CI, 0.388 to 0.897). In women, aggravation by emotional stress (OR, 0.348; 95% CI, 0.162 to 0.746) and dizziness (OR, 0. 457; 95% CI, 0.246 to 0.849) decreased the probability for OCAD. Conclusions: This is the first study to focus on gender differences in chest pain among Koreans with angina. Symptoms with high probability for OCAD were different between sexes. Our findings suggest that patient’s medical history in pretest assessment for OCAD should be individualized considering gender.

Original languageEnglish
Pages (from-to)582-592
Number of pages11
JournalKorean Journal of Internal Medicine
Volume35
Issue number3
DOIs
Publication statusPublished - 2020 May

Keywords

  • Angina pectoris
  • Chest pain
  • Coronary artery disease
  • Sex characteristics

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Cho, D. H., Choi, J., Kim, M. N., Kim, H. L., Kim, Y. H., Na, J. O., Jeong, J. O., Yoon, H. J., Shin, M. S., Kim, M. A., Hong, K. S., Shin, G. J., Park, S. M., & Shim, W. J. (2020). Gender differences in the presentation of chest pain in obstructive coronary artery disease: Results from the korean women’s chest pain registry. Korean Journal of Internal Medicine, 35(3), 582-592. https://doi.org/10.3904/kjim.2018.320