Abstract
Objective: The aim of this study was to determine the gene-environment interactions of smoking and shared epitope (SE) both separately and combined on anti-cyclic citrullinated peptide (CCP) antibodies in patients with rheumatoid arthritis (RA). Methods: The literature was searched using the MEDLINE, EMBASE and Cochrane databases. A meta-analysis on the associations between tobacco exposure (TE) and/or SE and the development of anti-CCP antibodies in patients with RA was performed. Results: Eight comparison studies with 5317 RA patients were considered in this meta-analysis. The odds ratio (OR) for positive anti-CCP antibodies in TE+/SE- patients with RA was increased compared with TE-/SE- patients (OR = 1.373, 95% CI = 1.111-1.698, P = 0.003). The ORs for positive anti-CCP antibodies in TE-/SE+ patients and TE+/SE+ patients with RA were also increased compared with TE-/SE- patients (OR = 2.678, 95% CI = 2.031-3.532, P < 1.0 × 10-9 in TE-/SE+; OR = 4.233, 95% CI = 2.458-7.291, P = 1.9 × 10-8 in TE+/SE+). Stratification by ethnicity indicated the same pattern as that shown in the overall group. The OR for positive anti-CCP antibodies in TE+/SE+ patients with RA was much higher than in TE-/SE- patients in Europeans and Asians (OR = 3.879, 95% CI = 2.203-6.830, P = 2.6 × 10-7; OR = 10.504, 95% CI = 3.182-34.67, P = 1.1 × 10-4). Conclusions: This meta-analysis suggests a gene-environmental interaction between smoking and SE for the development of anti-CCP antibodies.
| Original language | English |
|---|---|
| Pages (from-to) | 528-535 |
| Number of pages | 8 |
| Journal | International Journal of Rheumatic Diseases |
| Volume | 17 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2014 Jan 1 |
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Keywords
- Anti-CCP antibodies
- Rheumatoid arthritis
- Shared epitope
- Smoking
ASJC Scopus subject areas
- Rheumatology
Cite this
Gene-environmental interaction between smoking and shared epitope on the development of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis : A meta-analysis. / Lee, Young Ho; Bae, Sang Cheol; Song, Gwan Gyu.
In: International Journal of Rheumatic Diseases, Vol. 17, No. 5, 01.01.2014, p. 528-535.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gene-environmental interaction between smoking and shared epitope on the development of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis
T2 - A meta-analysis
AU - Lee, Young Ho
AU - Bae, Sang Cheol
AU - Song, Gwan Gyu
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Objective: The aim of this study was to determine the gene-environment interactions of smoking and shared epitope (SE) both separately and combined on anti-cyclic citrullinated peptide (CCP) antibodies in patients with rheumatoid arthritis (RA). Methods: The literature was searched using the MEDLINE, EMBASE and Cochrane databases. A meta-analysis on the associations between tobacco exposure (TE) and/or SE and the development of anti-CCP antibodies in patients with RA was performed. Results: Eight comparison studies with 5317 RA patients were considered in this meta-analysis. The odds ratio (OR) for positive anti-CCP antibodies in TE+/SE- patients with RA was increased compared with TE-/SE- patients (OR = 1.373, 95% CI = 1.111-1.698, P = 0.003). The ORs for positive anti-CCP antibodies in TE-/SE+ patients and TE+/SE+ patients with RA were also increased compared with TE-/SE- patients (OR = 2.678, 95% CI = 2.031-3.532, P < 1.0 × 10-9 in TE-/SE+; OR = 4.233, 95% CI = 2.458-7.291, P = 1.9 × 10-8 in TE+/SE+). Stratification by ethnicity indicated the same pattern as that shown in the overall group. The OR for positive anti-CCP antibodies in TE+/SE+ patients with RA was much higher than in TE-/SE- patients in Europeans and Asians (OR = 3.879, 95% CI = 2.203-6.830, P = 2.6 × 10-7; OR = 10.504, 95% CI = 3.182-34.67, P = 1.1 × 10-4). Conclusions: This meta-analysis suggests a gene-environmental interaction between smoking and SE for the development of anti-CCP antibodies.
AB - Objective: The aim of this study was to determine the gene-environment interactions of smoking and shared epitope (SE) both separately and combined on anti-cyclic citrullinated peptide (CCP) antibodies in patients with rheumatoid arthritis (RA). Methods: The literature was searched using the MEDLINE, EMBASE and Cochrane databases. A meta-analysis on the associations between tobacco exposure (TE) and/or SE and the development of anti-CCP antibodies in patients with RA was performed. Results: Eight comparison studies with 5317 RA patients were considered in this meta-analysis. The odds ratio (OR) for positive anti-CCP antibodies in TE+/SE- patients with RA was increased compared with TE-/SE- patients (OR = 1.373, 95% CI = 1.111-1.698, P = 0.003). The ORs for positive anti-CCP antibodies in TE-/SE+ patients and TE+/SE+ patients with RA were also increased compared with TE-/SE- patients (OR = 2.678, 95% CI = 2.031-3.532, P < 1.0 × 10-9 in TE-/SE+; OR = 4.233, 95% CI = 2.458-7.291, P = 1.9 × 10-8 in TE+/SE+). Stratification by ethnicity indicated the same pattern as that shown in the overall group. The OR for positive anti-CCP antibodies in TE+/SE+ patients with RA was much higher than in TE-/SE- patients in Europeans and Asians (OR = 3.879, 95% CI = 2.203-6.830, P = 2.6 × 10-7; OR = 10.504, 95% CI = 3.182-34.67, P = 1.1 × 10-4). Conclusions: This meta-analysis suggests a gene-environmental interaction between smoking and SE for the development of anti-CCP antibodies.
KW - Anti-CCP antibodies
KW - Rheumatoid arthritis
KW - Shared epitope
KW - Smoking
UR - http://www.scopus.com/inward/record.url?scp=84904325776&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84904325776&partnerID=8YFLogxK
U2 - 10.1111/1756-185X.12307
DO - 10.1111/1756-185X.12307
M3 - Article
C2 - 24618101
AN - SCOPUS:84904325776
VL - 17
SP - 528
EP - 535
JO - International Journal of Rheumatic Diseases
JF - International Journal of Rheumatic Diseases
SN - 1756-1841
IS - 5
ER -