Gene-environmental interaction between smoking and shared epitope on the development of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis: A meta-analysis

Young Ho Lee, Sang Cheol Bae, Gwan Gyu Song

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective: The aim of this study was to determine the gene-environment interactions of smoking and shared epitope (SE) both separately and combined on anti-cyclic citrullinated peptide (CCP) antibodies in patients with rheumatoid arthritis (RA). Methods: The literature was searched using the MEDLINE, EMBASE and Cochrane databases. A meta-analysis on the associations between tobacco exposure (TE) and/or SE and the development of anti-CCP antibodies in patients with RA was performed. Results: Eight comparison studies with 5317 RA patients were considered in this meta-analysis. The odds ratio (OR) for positive anti-CCP antibodies in TE+/SE- patients with RA was increased compared with TE-/SE- patients (OR = 1.373, 95% CI = 1.111-1.698, P = 0.003). The ORs for positive anti-CCP antibodies in TE-/SE+ patients and TE+/SE+ patients with RA were also increased compared with TE-/SE- patients (OR = 2.678, 95% CI = 2.031-3.532, P < 1.0 × 10-9 in TE-/SE+; OR = 4.233, 95% CI = 2.458-7.291, P = 1.9 × 10-8 in TE+/SE+). Stratification by ethnicity indicated the same pattern as that shown in the overall group. The OR for positive anti-CCP antibodies in TE+/SE+ patients with RA was much higher than in TE-/SE- patients in Europeans and Asians (OR = 3.879, 95% CI = 2.203-6.830, P = 2.6 × 10-7; OR = 10.504, 95% CI = 3.182-34.67, P = 1.1 × 10-4). Conclusions: This meta-analysis suggests a gene-environmental interaction between smoking and SE for the development of anti-CCP antibodies.

Original languageEnglish
Pages (from-to)528-535
Number of pages8
JournalInternational Journal of Rheumatic Diseases
Volume17
Issue number5
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Meta-Analysis
Epitopes
Rheumatoid Arthritis
Smoking
Tobacco
Antibodies
Genes
Odds Ratio
cyclic citrullinated peptide
Gene-Environment Interaction
MEDLINE
Databases

Keywords

  • Anti-CCP antibodies
  • Rheumatoid arthritis
  • Shared epitope
  • Smoking

ASJC Scopus subject areas

  • Rheumatology

Cite this

@article{d892bd4b189442cd853508338f7706cf,
title = "Gene-environmental interaction between smoking and shared epitope on the development of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis: A meta-analysis",
abstract = "Objective: The aim of this study was to determine the gene-environment interactions of smoking and shared epitope (SE) both separately and combined on anti-cyclic citrullinated peptide (CCP) antibodies in patients with rheumatoid arthritis (RA). Methods: The literature was searched using the MEDLINE, EMBASE and Cochrane databases. A meta-analysis on the associations between tobacco exposure (TE) and/or SE and the development of anti-CCP antibodies in patients with RA was performed. Results: Eight comparison studies with 5317 RA patients were considered in this meta-analysis. The odds ratio (OR) for positive anti-CCP antibodies in TE+/SE- patients with RA was increased compared with TE-/SE- patients (OR = 1.373, 95{\%} CI = 1.111-1.698, P = 0.003). The ORs for positive anti-CCP antibodies in TE-/SE+ patients and TE+/SE+ patients with RA were also increased compared with TE-/SE- patients (OR = 2.678, 95{\%} CI = 2.031-3.532, P < 1.0 × 10-9 in TE-/SE+; OR = 4.233, 95{\%} CI = 2.458-7.291, P = 1.9 × 10-8 in TE+/SE+). Stratification by ethnicity indicated the same pattern as that shown in the overall group. The OR for positive anti-CCP antibodies in TE+/SE+ patients with RA was much higher than in TE-/SE- patients in Europeans and Asians (OR = 3.879, 95{\%} CI = 2.203-6.830, P = 2.6 × 10-7; OR = 10.504, 95{\%} CI = 3.182-34.67, P = 1.1 × 10-4). Conclusions: This meta-analysis suggests a gene-environmental interaction between smoking and SE for the development of anti-CCP antibodies.",
keywords = "Anti-CCP antibodies, Rheumatoid arthritis, Shared epitope, Smoking",
author = "Lee, {Young Ho} and Bae, {Sang Cheol} and Song, {Gwan Gyu}",
year = "2014",
month = "1",
day = "1",
doi = "10.1111/1756-185X.12307",
language = "English",
volume = "17",
pages = "528--535",
journal = "International Journal of Rheumatic Diseases",
issn = "1756-1841",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Gene-environmental interaction between smoking and shared epitope on the development of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis

T2 - A meta-analysis

AU - Lee, Young Ho

AU - Bae, Sang Cheol

AU - Song, Gwan Gyu

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Objective: The aim of this study was to determine the gene-environment interactions of smoking and shared epitope (SE) both separately and combined on anti-cyclic citrullinated peptide (CCP) antibodies in patients with rheumatoid arthritis (RA). Methods: The literature was searched using the MEDLINE, EMBASE and Cochrane databases. A meta-analysis on the associations between tobacco exposure (TE) and/or SE and the development of anti-CCP antibodies in patients with RA was performed. Results: Eight comparison studies with 5317 RA patients were considered in this meta-analysis. The odds ratio (OR) for positive anti-CCP antibodies in TE+/SE- patients with RA was increased compared with TE-/SE- patients (OR = 1.373, 95% CI = 1.111-1.698, P = 0.003). The ORs for positive anti-CCP antibodies in TE-/SE+ patients and TE+/SE+ patients with RA were also increased compared with TE-/SE- patients (OR = 2.678, 95% CI = 2.031-3.532, P < 1.0 × 10-9 in TE-/SE+; OR = 4.233, 95% CI = 2.458-7.291, P = 1.9 × 10-8 in TE+/SE+). Stratification by ethnicity indicated the same pattern as that shown in the overall group. The OR for positive anti-CCP antibodies in TE+/SE+ patients with RA was much higher than in TE-/SE- patients in Europeans and Asians (OR = 3.879, 95% CI = 2.203-6.830, P = 2.6 × 10-7; OR = 10.504, 95% CI = 3.182-34.67, P = 1.1 × 10-4). Conclusions: This meta-analysis suggests a gene-environmental interaction between smoking and SE for the development of anti-CCP antibodies.

AB - Objective: The aim of this study was to determine the gene-environment interactions of smoking and shared epitope (SE) both separately and combined on anti-cyclic citrullinated peptide (CCP) antibodies in patients with rheumatoid arthritis (RA). Methods: The literature was searched using the MEDLINE, EMBASE and Cochrane databases. A meta-analysis on the associations between tobacco exposure (TE) and/or SE and the development of anti-CCP antibodies in patients with RA was performed. Results: Eight comparison studies with 5317 RA patients were considered in this meta-analysis. The odds ratio (OR) for positive anti-CCP antibodies in TE+/SE- patients with RA was increased compared with TE-/SE- patients (OR = 1.373, 95% CI = 1.111-1.698, P = 0.003). The ORs for positive anti-CCP antibodies in TE-/SE+ patients and TE+/SE+ patients with RA were also increased compared with TE-/SE- patients (OR = 2.678, 95% CI = 2.031-3.532, P < 1.0 × 10-9 in TE-/SE+; OR = 4.233, 95% CI = 2.458-7.291, P = 1.9 × 10-8 in TE+/SE+). Stratification by ethnicity indicated the same pattern as that shown in the overall group. The OR for positive anti-CCP antibodies in TE+/SE+ patients with RA was much higher than in TE-/SE- patients in Europeans and Asians (OR = 3.879, 95% CI = 2.203-6.830, P = 2.6 × 10-7; OR = 10.504, 95% CI = 3.182-34.67, P = 1.1 × 10-4). Conclusions: This meta-analysis suggests a gene-environmental interaction between smoking and SE for the development of anti-CCP antibodies.

KW - Anti-CCP antibodies

KW - Rheumatoid arthritis

KW - Shared epitope

KW - Smoking

UR - http://www.scopus.com/inward/record.url?scp=84904325776&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84904325776&partnerID=8YFLogxK

U2 - 10.1111/1756-185X.12307

DO - 10.1111/1756-185X.12307

M3 - Article

C2 - 24618101

AN - SCOPUS:84904325776

VL - 17

SP - 528

EP - 535

JO - International Journal of Rheumatic Diseases

JF - International Journal of Rheumatic Diseases

SN - 1756-1841

IS - 5

ER -