Gene expression and plasticity in the rat auditory cortex after bilateral cochlear ablation

Seung Ha Oh, Chong Sun Kim, Jae Jun Song

Research output: Contribution to journalArticle

13 Citations (Scopus)


Conclusion. The plastic changes in the auditory cortex after bilateral cochlear ablation are related to the immediate early genes as well as the neural plasticity-related genes. In addition, cross-modal plasticity may play an important role in the early changes in the auditory cortex after bilateral cochlear ablation. Objectives. The purpose of this study was to identify candidate genes involved in the normal development of primary auditory cortex during the critical period as well as those genes specifically modulated under conditions of sensory deafferentation by bilateral cochlear ablation. Materials and methods. We produced a bilaterally deaf rat model and used DNA microarray technology to analyze differential gene expression in the primary auditory cortex of bilateral cochlear ablated and sham-operated age-matched control rats. Gene expression in the auditory cortex was compared at 2, 4, and 12 weeks after surgery. For selected genes, the changes in gene expression were confirmed by real-time polymerase chain reaction (PCR). Results. In the cochlear ablation groups, the expression of immediate early genes (Egr1, 2, 3, 4, c-fos, etc.) and neural plasticity-related genes (Arc, Syngr1, Bdnf, etc.) was decreased at 2 weeks and increased at 4 weeks. The expression of neurotransmission-related genes (Gabra5, Chrnb3, Chrne, etc.) was decreased at 12 weeks.

Original languageEnglish
Pages (from-to)341-350
Number of pages10
JournalActa Oto-Laryngologica
Issue number4
Publication statusPublished - 2007 Apr 18



  • Auditory cortex
  • Central auditory system
  • Critical period
  • Damage protection
  • Deafness
  • Genes
  • Microarray analysis

ASJC Scopus subject areas

  • Otorhinolaryngology

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