Gene expression profile of aging and its retardation by caloric restriction

Cheol Koo Lee; Roger G. Klopp; Richard Weindruch; Tomas A. Prolla

doi:10.1126/science.285.5432.1390

Gene expression profile of aging and its retardation by caloric restriction

Cheol Koo Lee, Roger G. Klopp, Richard Weindruch, Tomas A. Prolla

Research output: Contribution to journal › Article › peer-review

1276 Citations (Scopus)

Abstract

The gene expression profile of the aging process was analyzed in skeletal muscle of mice. Use of high-density oligonucleotide arrays representing 6347 genes revealed that aging resulted in a differential gene expression pattern indicative of a marked stress response and lower expression of metabolic and biosynthetic genes. Most alterations were either completely or partially prevented by caloric restriction, the only intervention known to retard aging in mammals. Transcriptional patterns of calorie-restricted animals suggest that caloric restriction retards the aging process by causing a metabolic shift toward increased protein turnover and decreased macromolecular damage.

Original language	English
Pages (from-to)	1390-1393
Number of pages	4
Journal	Science
Volume	285
Issue number	5432
DOIs	https://doi.org/10.1126/science.285.5432.1390
Publication status	Published - 1999 Aug 27
Externally published	Yes

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AB - The gene expression profile of the aging process was analyzed in skeletal muscle of mice. Use of high-density oligonucleotide arrays representing 6347 genes revealed that aging resulted in a differential gene expression pattern indicative of a marked stress response and lower expression of metabolic and biosynthetic genes. Most alterations were either completely or partially prevented by caloric restriction, the only intervention known to retard aging in mammals. Transcriptional patterns of calorie-restricted animals suggest that caloric restriction retards the aging process by causing a metabolic shift toward increased protein turnover and decreased macromolecular damage.

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Gene expression profile of aging and its retardation by caloric restriction

Abstract

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