Gene expression profile of aging and its retardation by caloric restriction

Cheol-Koo Lee, Roger G. Klopp, Richard Weindruch, Tomas A. Prolla

Research output: Contribution to journalArticle

1201 Citations (Scopus)

Abstract

The gene expression profile of the aging process was analyzed in skeletal muscle of mice. Use of high-density oligonucleotide arrays representing 6347 genes revealed that aging resulted in a differential gene expression pattern indicative of a marked stress response and lower expression of metabolic and biosynthetic genes. Most alterations were either completely or partially prevented by caloric restriction, the only intervention known to retard aging in mammals. Transcriptional patterns of calorie-restricted animals suggest that caloric restriction retards the aging process by causing a metabolic shift toward increased protein turnover and decreased macromolecular damage.

Original languageEnglish
Pages (from-to)1390-1393
Number of pages4
JournalScience
Volume285
Issue number5432
DOIs
Publication statusPublished - 1999 Aug 27
Externally publishedYes

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Caloric Restriction
Transcriptome
Oligonucleotide Array Sequence Analysis
Genes
Mammals
Skeletal Muscle
Gene Expression
Proteins

ASJC Scopus subject areas

  • General

Cite this

Gene expression profile of aging and its retardation by caloric restriction. / Lee, Cheol-Koo; Klopp, Roger G.; Weindruch, Richard; Prolla, Tomas A.

In: Science, Vol. 285, No. 5432, 27.08.1999, p. 1390-1393.

Research output: Contribution to journalArticle

Lee, Cheol-Koo ; Klopp, Roger G. ; Weindruch, Richard ; Prolla, Tomas A. / Gene expression profile of aging and its retardation by caloric restriction. In: Science. 1999 ; Vol. 285, No. 5432. pp. 1390-1393.
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