Abstract
BACKGROUND: There has been a paucity of data about the difference in gene expression between melasma lesional skin and normal adjacent one.
OBJECTIVE: Our aim was to identify novel genes involved in the pathogenesis of melasma.
METHODS: We performed a microarray analysis and confirmed the results on quantitative real-time polymerase chain reaction (qRT-PCR) in Korean women with melasma.
RESULTS: There were 334 genes whose degree of expression showed a significant difference between melasma lesional skin and normal adjacent one. Of these, five were confirmed on qRT-PCR. In melasma lesional skin, there were down-regulation of genes involved in the PPAR signaling pathway and up-regulation of genes involved in neuronal component and the functions of stratum corneum barrier.
CONCLUSION: This result suggests that the pathogenesis of melasma might be associated with novel genes involved in the above signaling pathway in Korean women.
| Original language | English |
|---|---|
| Pages (from-to) | 333-342 |
| Number of pages | 10 |
| Journal | Dermatology (Basel, Switzerland) |
| Volume | 229 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2014 Jan 1 |
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ASJC Scopus subject areas
- Dermatology
Cite this
Gene expression profiling in melasma in Korean women. / Chung, Bo Young; Noh, Tai Kyung; Yang, Sang Hwa; Kim, Il-Hwan; Lee, Mi Woo; Yoon, Tae Jin; Chang, Sung Eun.
In: Dermatology (Basel, Switzerland), Vol. 229, No. 4, 01.01.2014, p. 333-342.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gene expression profiling in melasma in Korean women
AU - Chung, Bo Young
AU - Noh, Tai Kyung
AU - Yang, Sang Hwa
AU - Kim, Il-Hwan
AU - Lee, Mi Woo
AU - Yoon, Tae Jin
AU - Chang, Sung Eun
PY - 2014/1/1
Y1 - 2014/1/1
N2 - BACKGROUND: There has been a paucity of data about the difference in gene expression between melasma lesional skin and normal adjacent one.OBJECTIVE: Our aim was to identify novel genes involved in the pathogenesis of melasma.METHODS: We performed a microarray analysis and confirmed the results on quantitative real-time polymerase chain reaction (qRT-PCR) in Korean women with melasma.RESULTS: There were 334 genes whose degree of expression showed a significant difference between melasma lesional skin and normal adjacent one. Of these, five were confirmed on qRT-PCR. In melasma lesional skin, there were down-regulation of genes involved in the PPAR signaling pathway and up-regulation of genes involved in neuronal component and the functions of stratum corneum barrier.CONCLUSION: This result suggests that the pathogenesis of melasma might be associated with novel genes involved in the above signaling pathway in Korean women.
AB - BACKGROUND: There has been a paucity of data about the difference in gene expression between melasma lesional skin and normal adjacent one.OBJECTIVE: Our aim was to identify novel genes involved in the pathogenesis of melasma.METHODS: We performed a microarray analysis and confirmed the results on quantitative real-time polymerase chain reaction (qRT-PCR) in Korean women with melasma.RESULTS: There were 334 genes whose degree of expression showed a significant difference between melasma lesional skin and normal adjacent one. Of these, five were confirmed on qRT-PCR. In melasma lesional skin, there were down-regulation of genes involved in the PPAR signaling pathway and up-regulation of genes involved in neuronal component and the functions of stratum corneum barrier.CONCLUSION: This result suggests that the pathogenesis of melasma might be associated with novel genes involved in the above signaling pathway in Korean women.
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UR - http://www.scopus.com/inward/citedby.url?scp=84943391563&partnerID=8YFLogxK
U2 - 10.1159/000365080
DO - 10.1159/000365080
M3 - Article
C2 - 25472527
AN - SCOPUS:84917739603
VL - 229
SP - 333
EP - 342
JO - Dermatology
JF - Dermatology
SN - 1018-8665
IS - 4
ER -