Gene expression profiling in melasma in Korean women

Bo Young Chung; Tai Kyung Noh; Sang Hwa Yang; Il-Hwan Kim; Mi Woo Lee; Tae Jin Yoon; Sung Eun Chang

doi:10.1159/000365080

Gene expression profiling in melasma in Korean women

Bo Young Chung, Tai Kyung Noh, Sang Hwa Yang, Il-Hwan Kim, Mi Woo Lee, Tae Jin Yoon, Sung Eun Chang

Department of Dermatology

Research output: Contribution to journal › Article

6 Citations (Scopus)

Abstract

BACKGROUND: There has been a paucity of data about the difference in gene expression between melasma lesional skin and normal adjacent one.

OBJECTIVE: Our aim was to identify novel genes involved in the pathogenesis of melasma.

METHODS: We performed a microarray analysis and confirmed the results on quantitative real-time polymerase chain reaction (qRT-PCR) in Korean women with melasma.

RESULTS: There were 334 genes whose degree of expression showed a significant difference between melasma lesional skin and normal adjacent one. Of these, five were confirmed on qRT-PCR. In melasma lesional skin, there were down-regulation of genes involved in the PPAR signaling pathway and up-regulation of genes involved in neuronal component and the functions of stratum corneum barrier.

CONCLUSION: This result suggests that the pathogenesis of melasma might be associated with novel genes involved in the above signaling pathway in Korean women.

Original language	English
Pages (from-to)	333-342
Number of pages	10
Journal	Dermatology (Basel, Switzerland)
Volume	229
Issue number	4
DOIs	https://doi.org/10.1159/000365080
Publication status	Published - 2014 Jan 1

ASJC Scopus subject areas

Dermatology

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Chung, B. Y., Noh, T. K., Yang, S. H., Kim, I-H., Lee, M. W., Yoon, T. J., & Chang, S. E. (2014). Gene expression profiling in melasma in Korean women. Dermatology (Basel, Switzerland), 229(4), 333-342. https://doi.org/10.1159/000365080

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abstract = "BACKGROUND: There has been a paucity of data about the difference in gene expression between melasma lesional skin and normal adjacent one.OBJECTIVE: Our aim was to identify novel genes involved in the pathogenesis of melasma.METHODS: We performed a microarray analysis and confirmed the results on quantitative real-time polymerase chain reaction (qRT-PCR) in Korean women with melasma.RESULTS: There were 334 genes whose degree of expression showed a significant difference between melasma lesional skin and normal adjacent one. Of these, five were confirmed on qRT-PCR. In melasma lesional skin, there were down-regulation of genes involved in the PPAR signaling pathway and up-regulation of genes involved in neuronal component and the functions of stratum corneum barrier.CONCLUSION: This result suggests that the pathogenesis of melasma might be associated with novel genes involved in the above signaling pathway in Korean women.",

author = "Chung, {Bo Young} and Noh, {Tai Kyung} and Yang, {Sang Hwa} and Il-Hwan Kim and Lee, {Mi Woo} and Yoon, {Tae Jin} and Chang, {Sung Eun}",

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AU - Chung, Bo Young

AU - Noh, Tai Kyung

AU - Yang, Sang Hwa

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AU - Yoon, Tae Jin

AU - Chang, Sung Eun

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N2 - BACKGROUND: There has been a paucity of data about the difference in gene expression between melasma lesional skin and normal adjacent one.OBJECTIVE: Our aim was to identify novel genes involved in the pathogenesis of melasma.METHODS: We performed a microarray analysis and confirmed the results on quantitative real-time polymerase chain reaction (qRT-PCR) in Korean women with melasma.RESULTS: There were 334 genes whose degree of expression showed a significant difference between melasma lesional skin and normal adjacent one. Of these, five were confirmed on qRT-PCR. In melasma lesional skin, there were down-regulation of genes involved in the PPAR signaling pathway and up-regulation of genes involved in neuronal component and the functions of stratum corneum barrier.CONCLUSION: This result suggests that the pathogenesis of melasma might be associated with novel genes involved in the above signaling pathway in Korean women.

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