Gene expression profiling in melasma in Korean women

Bo Young Chung, Tai Kyung Noh, Sang Hwa Yang, Il-Hwan Kim, Mi Woo Lee, Tae Jin Yoon, Sung Eun Chang

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

BACKGROUND: There has been a paucity of data about the difference in gene expression between melasma lesional skin and normal adjacent one.

OBJECTIVE: Our aim was to identify novel genes involved in the pathogenesis of melasma.

METHODS: We performed a microarray analysis and confirmed the results on quantitative real-time polymerase chain reaction (qRT-PCR) in Korean women with melasma.

RESULTS: There were 334 genes whose degree of expression showed a significant difference between melasma lesional skin and normal adjacent one. Of these, five were confirmed on qRT-PCR. In melasma lesional skin, there were down-regulation of genes involved in the PPAR signaling pathway and up-regulation of genes involved in neuronal component and the functions of stratum corneum barrier.

CONCLUSION: This result suggests that the pathogenesis of melasma might be associated with novel genes involved in the above signaling pathway in Korean women.

Original languageEnglish
Pages (from-to)333-342
Number of pages10
JournalDermatology (Basel, Switzerland)
Volume229
Issue number4
DOIs
Publication statusPublished - 2014 Jan 1

ASJC Scopus subject areas

  • Dermatology

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