Gene expression profiling in melasma in Korean women

Bo Young Chung, Tai Kyung Noh, Sang Hwa Yang, Il-Hwan Kim, Mi Woo Lee, Tae Jin Yoon, Sung Eun Chang

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

BACKGROUND: There has been a paucity of data about the difference in gene expression between melasma lesional skin and normal adjacent one.

OBJECTIVE: Our aim was to identify novel genes involved in the pathogenesis of melasma.

METHODS: We performed a microarray analysis and confirmed the results on quantitative real-time polymerase chain reaction (qRT-PCR) in Korean women with melasma.

RESULTS: There were 334 genes whose degree of expression showed a significant difference between melasma lesional skin and normal adjacent one. Of these, five were confirmed on qRT-PCR. In melasma lesional skin, there were down-regulation of genes involved in the PPAR signaling pathway and up-regulation of genes involved in neuronal component and the functions of stratum corneum barrier.

CONCLUSION: This result suggests that the pathogenesis of melasma might be associated with novel genes involved in the above signaling pathway in Korean women.

Original languageEnglish
Pages (from-to)333-342
Number of pages10
JournalDermatology (Basel, Switzerland)
Volume229
Issue number4
DOIs
Publication statusPublished - 2014 Jan 1

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Melanosis
Gene Expression Profiling
Genes
Skin
Real-Time Polymerase Chain Reaction
Peroxisome Proliferator-Activated Receptors
Microarray Analysis
Cornea
Up-Regulation
Down-Regulation
Gene Expression

ASJC Scopus subject areas

  • Dermatology

Cite this

Chung, B. Y., Noh, T. K., Yang, S. H., Kim, I-H., Lee, M. W., Yoon, T. J., & Chang, S. E. (2014). Gene expression profiling in melasma in Korean women. Dermatology (Basel, Switzerland), 229(4), 333-342. https://doi.org/10.1159/000365080

Gene expression profiling in melasma in Korean women. / Chung, Bo Young; Noh, Tai Kyung; Yang, Sang Hwa; Kim, Il-Hwan; Lee, Mi Woo; Yoon, Tae Jin; Chang, Sung Eun.

In: Dermatology (Basel, Switzerland), Vol. 229, No. 4, 01.01.2014, p. 333-342.

Research output: Contribution to journalArticle

Chung, BY, Noh, TK, Yang, SH, Kim, I-H, Lee, MW, Yoon, TJ & Chang, SE 2014, 'Gene expression profiling in melasma in Korean women', Dermatology (Basel, Switzerland), vol. 229, no. 4, pp. 333-342. https://doi.org/10.1159/000365080
Chung, Bo Young ; Noh, Tai Kyung ; Yang, Sang Hwa ; Kim, Il-Hwan ; Lee, Mi Woo ; Yoon, Tae Jin ; Chang, Sung Eun. / Gene expression profiling in melasma in Korean women. In: Dermatology (Basel, Switzerland). 2014 ; Vol. 229, No. 4. pp. 333-342.
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