Gene expression profiling in melasma in Korean women

Bo Young Chung, Tai Kyung Noh, Sang Hwa Yang, Il Hwan Kim, Mi Woo Lee, Tae Jin Yoon, Sung Eun Chang

    Research output: Contribution to journalArticlepeer-review

    11 Citations (Scopus)

    Abstract

    Background: There has been a paucity of data about the difference in gene expression between melasma lesional skin and normal adjacent one. Objective: Our aim was to identify novel genes involved in the pathogenesis of melasma. Methods: We performed a microarray analysis and confirmed the results on quantitative real-time polymerase chain reaction (qRT-PCR) in Korean women with melasma. Results: There were 334 genes whose degree of expression showed a significant difference between melasma lesional skin and normal adjacent one. Of these, five were confirmed on qRT-PCR. In melasma lesional skin, there were down-regulation of genes involved in the PPAR signaling pathway and up-regulation of genes involved in neuronal component and the functions of stratum corneum barrier. Conclusion: This result suggests that the pathogenesis of melasma might be associated with novel genes involved in the above signaling pathway in Korean women.

    Original languageEnglish
    Pages (from-to)333-342
    Number of pages10
    JournalDermatology
    Volume229
    Issue number4
    DOIs
    Publication statusPublished - 2014 May 22

    Keywords

    • Melasma
    • Microarray analysis
    • Pathogenesis

    ASJC Scopus subject areas

    • Dermatology

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