Gene expression profiling of aging using DNA microarrays

Richard Weindruch, Tsuyoshi Kayo, Cheol-Koo Lee, Tomas A. Prolla

Research output: Contribution to journalArticle

128 Citations (Scopus)

Abstract

We have previously employed high density oligonucleotide arrays representing thousands of genes to determine the gene expression profile of the aging process in skeletal muscle (gastrocnemius) and brain (cerebellum and neocortex) of male C57BL/6 mice. Specific gene expression profiles are associated with the aging process of individual organs, and caloric restriction can prevent or retard the establishment of these gene expression alterations. The use of DNA microarrays may provide a new tool to measure biological age on a tissue-specific basis and to evaluate at the molecular level the efficacy of interventions designed to retard the aging process.

Original languageEnglish
Pages (from-to)177-193
Number of pages17
JournalMechanisms of Ageing and Development
Volume123
Issue number2-3
DOIs
Publication statusPublished - 2002 Jan 1
Externally publishedYes

Fingerprint

Gene Expression Profiling
Microarrays
Oligonucleotide Array Sequence Analysis
Transcriptome
Gene expression
Aging of materials
Caloric Restriction
DNA
Neocortex
Inbred C57BL Mouse
Cerebellum
Skeletal Muscle
Gene Expression
Oligonucleotides
Muscle
Brain
Genes
Tissue

Keywords

  • Aging
  • Brain
  • Caloric restriction
  • DNA microarrays
  • Gene expression
  • Muscle

ASJC Scopus subject areas

  • Ageing
  • Biochemistry
  • Developmental Biology
  • Developmental Neuroscience

Cite this

Gene expression profiling of aging using DNA microarrays. / Weindruch, Richard; Kayo, Tsuyoshi; Lee, Cheol-Koo; Prolla, Tomas A.

In: Mechanisms of Ageing and Development, Vol. 123, No. 2-3, 01.01.2002, p. 177-193.

Research output: Contribution to journalArticle

Weindruch, Richard ; Kayo, Tsuyoshi ; Lee, Cheol-Koo ; Prolla, Tomas A. / Gene expression profiling of aging using DNA microarrays. In: Mechanisms of Ageing and Development. 2002 ; Vol. 123, No. 2-3. pp. 177-193.
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