Gene expression profiling of aging using DNA microarrays

Richard Weindruch, Tsuyoshi Kayo, Cheol-Koo Lee, Tomas A. Prolla

Research output: Contribution to journalArticle

130 Citations (Scopus)

Abstract

We have previously employed high density oligonucleotide arrays representing thousands of genes to determine the gene expression profile of the aging process in skeletal muscle (gastrocnemius) and brain (cerebellum and neocortex) of male C57BL/6 mice. Specific gene expression profiles are associated with the aging process of individual organs, and caloric restriction can prevent or retard the establishment of these gene expression alterations. The use of DNA microarrays may provide a new tool to measure biological age on a tissue-specific basis and to evaluate at the molecular level the efficacy of interventions designed to retard the aging process.

Original languageEnglish
Pages (from-to)177-193
Number of pages17
JournalMechanisms of Ageing and Development
Volume123
Issue number2-3
DOIs
Publication statusPublished - 2002 Jan 1
Externally publishedYes

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Keywords

  • Aging
  • Brain
  • Caloric restriction
  • DNA microarrays
  • Gene expression
  • Muscle

ASJC Scopus subject areas

  • Ageing
  • Biochemistry
  • Developmental Biology
  • Developmental Neuroscience

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