Generation of an induced pluripotent stem cell (iPSC) line from a 42-year-old adult cerebral type X-linked adrenoleukodystrophy (X-ALD) patient

Gyu Bum Yeon, Daryeon Son, Phil Jun Kang, Seung Min Oh, Hun Lim, Hoon Chul Kang, Seungkwon You, Dae Sung Kim

Research output: Contribution to journalArticle

Abstract

X-linked Adrenoleukodystrophy (X-ALD) is a neuro-metabolic disorder that is caused by malfunction of a peroxisomal transporter protein, adenosine ATP-binding cassette transporter superfamily D member 1 (ABCD1). We established an induced pluripotent stem cell (iPSC) line from a 42-year-old male X-ALD patient-derived dermal fibroblasts with Sendai virus-mediated reprogramming. Established iPSCs stably expanded, expressed genes of pluripotency, and maintained normal karyotype. In vitro differentiation assay revealed the characteristics of all three germ layers.

Original languageEnglish
Article number101425
JournalStem Cell Research
Volume36
DOIs
Publication statusPublished - 2019 Apr

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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