Generation of an induced pluripotent stem cell line KUMCi001-A from CD34+ bone marrow cells of a patient with acute lymphoblastic leukemia using human placenta-derived cell conditioned medium

Seung Jin Lee, Ka Won Kang, Ji Hea Kim, Young Park, Byung Soo Kim

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Many patients with acute lymphoblastic leukemia (ALL) show relapse post-chemotherapy. Therefore, it is important to develop a human induced pluripotent stem cell (hiPSC) line from ALL cells to verify the pathophysiology. However, the low efficiency of the established reprogramming protocol has hampered the development of ALL hiPSC lines. Our recently reported novel reprogramming method, using human placenta-derived cell conditioned medium (hPCCM), offers a relatively higher efficiency in humanized conditions. Here, we generated an hiPSC line from ALL-derived CD34+ bone marrow cells, using hPCCM for reprogramming. This hiPSC line might be a useful model for studies on ALL.

Original languageEnglish
Article number101913
JournalStem Cell Research
Volume47
DOIs
Publication statusPublished - 2020 Aug

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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