Generation of chitosan microfiber for bio-artificial liver microchip

Kwang Ho Lee, Su Jung Shin, Da Yoon No, Chang Beom Kim, Jung Kyung Kim, Yong Woo Cho, Bong Geun Chung, Seok Chung, Roger D. Kamm, Sang Hoon Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We demonstrate a method to create microscale chitosan fiber by combining a microfluidic device and in situ formation of a 2D shape by winding around the frame. The diameter of these fibers was found to range from a few tenths to hundredths of a micrometer, and the process was optimized to fabricate long (> 1 meter) fibrous chitosan fibers and to wind them. To estimate the capability of these fibers to act as scaffolding for liver tissue formation, HepG2 cells, which are generally used as model for assay of liver function were seeded onto the fibers and cultured.

Original languageEnglish
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages1319-1321
Number of pages3
Publication statusPublished - 2010
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
Duration: 2010 Oct 32010 Oct 7

Publication series

Name14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Volume2

Other

Other14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
CountryNetherlands
CityGroningen
Period10/10/310/10/7

Keywords

  • Bio-artificial liver chip
  • Chitosan microfiber
  • Liver specific function

ASJC Scopus subject areas

  • Control and Systems Engineering

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