@article{7a8da4a25e90493aa227d4d79ab1feda,
title = "Generation of cytochrome P450 polymorphic human induced pluripotent stem cell lines with defective CYP activities",
abstract = "Single nucleotide polymorphisms (SNPs) in cytochrome P450 (CYP) isoenzymes alter drug metabolism and pharmacodynamics. In particular, several SNPs within CYPs decrease CYP activities, resulting in a high plasma concentration of drugs and increasing adverse effect of commonly used drugs. Here, we generated two different human induced pluripotent stem cell (hiPSC) lines, which retain defective CYP2C19 or CYP3A5 activities individually. These two hiPSC lines could be valuable sources for understading the interindividual variability in drug responses caused by SNP-induced alteration in CYP activites.",
author = "Jaehun Lee and Woo, {Dong Hun} and Park, {Han Jin} and Ko, {Duck Sung} and Kim, {Jong Hoon}",
note = "Funding Information: This study was provided with bioresources from National Biobank of Korea, the Centers for Disease Control and Prevention (2017-045), Republic of Korea. We would like to thank Bom-Yi Lee and So-Yeon Park (Laboratory of Medical Genetics, Cheil General Hospital and Women's Healthcare Center) for technical support in karyotype analysis. This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MEST) (No. 2017M3A9B4042581 and 2018M3A9H1019504). Funding Information: This study was provided with bioresources from National Biobank of Korea, the Centers for Disease Control and Prevention ( 2017-045 ), Republic of Korea. We would like to thank Bom-Yi Lee and So-Yeon Park (Laboratory of Medical Genetics, Cheil General Hospital and Women's Healthcare Center) for technical support in karyotype analysis. This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MEST) (No. 2017M3A9B4042581 and 2018M3A9H1019504 ).",
year = "2018",
month = aug,
doi = "10.1016/j.scr.2018.07.010",
language = "English",
volume = "31",
pages = "117--121",
journal = "Stem Cell Research",
issn = "1873-5061",
publisher = "Elsevier",
}