Generation of digitized microfluidic filling flow by vent control

Junghyo Yoon, Eundoo Lee, Jaehoon Kim, Sewoon Han, Seok Chung

Research output: Contribution to journalArticle

Abstract

Quantitative microfluidic point-of-care testing has been translated into clinical applications to support a prompt decision on patient treatment. A nanointerstice-driven filling technique has been developed to realize the fast and robust filling of microfluidic channels with liquid samples, but it has failed to provide a consistent filling time owing to the wide variation in liquid viscosity, resulting in an increase in quantification errors. There is a strong demand for simple and quick flow control to ensure accurate quantification, without a serious increase in system complexity. A new control mechanism employing two-beam refraction and one solenoid valve was developed and found to successfully generate digitized filling flow, completely free from errors due to changes in viscosity. The validity of digitized filling flow was evaluated by the immunoassay, using liquids with a wide range of viscosity. This digitized microfluidic filling flow is a novel approach that could be applied in conventional microfluidic point-of-care testing.

Original languageEnglish
JournalBiosensors and Bioelectronics
DOIs
Publication statusAccepted/In press - 2016 Aug 30

Fingerprint

Microfluidics
Vents
Viscosity
Immunoassay
Patient treatment
Solenoid valves
Viscosity of liquids
Liquids
Testing
Refraction
Flow control
Point-of-Care Testing
Therapeutics

Keywords

  • Digitized fluidic filling
  • Immunoassay
  • Microfluidic channel filling
  • Nanointerstice

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry

Cite this

Generation of digitized microfluidic filling flow by vent control. / Yoon, Junghyo; Lee, Eundoo; Kim, Jaehoon; Han, Sewoon; Chung, Seok.

In: Biosensors and Bioelectronics, 30.08.2016.

Research output: Contribution to journalArticle

Yoon, Junghyo ; Lee, Eundoo ; Kim, Jaehoon ; Han, Sewoon ; Chung, Seok. / Generation of digitized microfluidic filling flow by vent control. In: Biosensors and Bioelectronics. 2016.
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