Generation of human induced iPSC KUMi003-A from acute promyelocytic leukemia (APL) M3

Ji Hea Kim, Ka Won Kang, Byung Hyun Lee, Young Park, Byung Soo Kim

Research output: Contribution to journalArticlepeer-review

Abstract

Acute promyelocytic leukemia (APL) M3 is an acute myeloid leukemia (AML) subtype and is characterized by the chromosomal translocation t(15;17)(p22;q11), which results in the fusion of the promyelocytic gene (PML) at 15q22 with the retinoic acid α-receptor gene (RARA) at 17q21. We generated an induced pluripotent stem cell line “KUMi003-A” from an APL M3 patient that is pluripotent and can differentiate into the three germ layers. This iPSC line will be useful as a disease model to investigate disease mechanisms specific to APL M3.

Original languageEnglish
Article number102861
JournalStem Cell Research
Volume63
DOIs
Publication statusPublished - 2022 Aug

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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