Generation of induced pluripotent stem cell (iPSC) line from a 21-year-old X-linked adrenoleukodystrophy (X-ALD) patient

Young Rang You, Daryeon Son, Phil Jun Kang, Seungkwon You, Dae-Sung Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

X-linked Adrenoleukodystrophy (X-ALD) is a genetic disease that caused by mutations in adenosine triphosphate [ATP]-binding-cassette transporter superfamily D member 1 (ABCD1) gene. We generated an induced pluripotent stem cell (iPSC) line from a 21-year-old male X-ALD patient-derived fibroblasts by Sendai virus mediated reprogramming. Established iPSCs stably expanded while maintaining immunoreactivity for various pluripotency markers and alkaline phosphatase, as well as normal 44 + XY karyotype. Under the differentiation condition, the cells gave rise to cells of three germ layers.

Original languageEnglish
Pages (from-to)136-138
Number of pages3
JournalStem Cell Research
Volume25
DOIs
Publication statusPublished - 2017 Dec 1

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Adrenoleukodystrophy
Induced Pluripotent Stem Cells
Sendai virus
Cell Line
Germ Layers
Inborn Genetic Diseases
Karyotype
Alkaline Phosphatase
Fibroblasts
Adenosine Triphosphate
Mutation
Genes

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Generation of induced pluripotent stem cell (iPSC) line from a 21-year-old X-linked adrenoleukodystrophy (X-ALD) patient. / You, Young Rang; Son, Daryeon; Kang, Phil Jun; You, Seungkwon; Kim, Dae-Sung.

In: Stem Cell Research, Vol. 25, 01.12.2017, p. 136-138.

Research output: Contribution to journalArticle

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