Generation of induced pluripotent stem cell line KUMi002-A with normal karyotype from a patient with Philadelphia chromosome-positive chronic myeloid leukemia

Ji Hea Kim; Ka Won Kang; Byung Hyun Lee; Young Park; Byung Soo Kim

doi:10.1016/j.scr.2021.102465

Generation of induced pluripotent stem cell line KUMi002-A with normal karyotype from a patient with Philadelphia chromosome-positive chronic myeloid leukemia

Ji Hea Kim, Ka Won Kang, Byung Hyun Lee, Young Park, Byung Soo Kim

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Chronic myeloid leukemia (CML) is caused by the dysregulated tyrosine kinase activity of the BCR-ABL fusion protein. In this study, we generated induced pluripotent stem cells (iPSCs) with a normal karyotype, using cells from a patient with CML and a Philadelphia chromosome. These human iPSCs showed positive pluripotency markers and differentiated into three germ layers. This iPSC line can be useful for the study of CML, namely the biology of hematopoietic stem cells with normal karyotype in CML, and for the development of patient-specific immunological treatment.

Original language	English
Article number	102465
Journal	Stem Cell Research
Volume	55
DOIs	https://doi.org/10.1016/j.scr.2021.102465
Publication status	Published - 2021 Aug

ASJC Scopus subject areas

Developmental Biology
Cell Biology

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title = "Generation of induced pluripotent stem cell line KUMi002-A with normal karyotype from a patient with Philadelphia chromosome-positive chronic myeloid leukemia",

abstract = "Chronic myeloid leukemia (CML) is caused by the dysregulated tyrosine kinase activity of the BCR-ABL fusion protein. In this study, we generated induced pluripotent stem cells (iPSCs) with a normal karyotype, using cells from a patient with CML and a Philadelphia chromosome. These human iPSCs showed positive pluripotency markers and differentiated into three germ layers. This iPSC line can be useful for the study of CML, namely the biology of hematopoietic stem cells with normal karyotype in CML, and for the development of patient-specific immunological treatment.",

author = "Kim, {Ji Hea} and Kang, {Ka Won} and Lee, {Byung Hyun} and Young Park and Kim, {Byung Soo}",

note = "Funding Information: This study was supported by the Bio & Medical Technology Development Program of the National Research Foundation, funded by the Ministry of Science and ICT (2017M3A9C8060403). Publisher Copyright: {\textcopyright} 2021 The Author(s)",

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month = aug,

doi = "10.1016/j.scr.2021.102465",

language = "English",

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journal = "Stem Cell Research",

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AU - Kim, Ji Hea

AU - Kang, Ka Won

AU - Lee, Byung Hyun

AU - Park, Young

AU - Kim, Byung Soo

N1 - Funding Information: This study was supported by the Bio & Medical Technology Development Program of the National Research Foundation, funded by the Ministry of Science and ICT (2017M3A9C8060403). Publisher Copyright: © 2021 The Author(s)

PY - 2021/8

Y1 - 2021/8

N2 - Chronic myeloid leukemia (CML) is caused by the dysregulated tyrosine kinase activity of the BCR-ABL fusion protein. In this study, we generated induced pluripotent stem cells (iPSCs) with a normal karyotype, using cells from a patient with CML and a Philadelphia chromosome. These human iPSCs showed positive pluripotency markers and differentiated into three germ layers. This iPSC line can be useful for the study of CML, namely the biology of hematopoietic stem cells with normal karyotype in CML, and for the development of patient-specific immunological treatment.

AB - Chronic myeloid leukemia (CML) is caused by the dysregulated tyrosine kinase activity of the BCR-ABL fusion protein. In this study, we generated induced pluripotent stem cells (iPSCs) with a normal karyotype, using cells from a patient with CML and a Philadelphia chromosome. These human iPSCs showed positive pluripotency markers and differentiated into three germ layers. This iPSC line can be useful for the study of CML, namely the biology of hematopoietic stem cells with normal karyotype in CML, and for the development of patient-specific immunological treatment.

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SN - 1873-5061

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JO - Stem Cell Research

JF - Stem Cell Research

M1 - 102465

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Generation of induced pluripotent stem cell line KUMi002-A with normal karyotype from a patient with Philadelphia chromosome-positive chronic myeloid leukemia

Abstract

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