Generation of induced pluripotent stem cell line KUMi002-A with normal karyotype from a patient with Philadelphia chromosome-positive chronic myeloid leukemia

Ji Hea Kim, Ka Won Kang, Byung Hyun Lee, Young Park, Byung Soo Kim

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic myeloid leukemia (CML) is caused by the dysregulated tyrosine kinase activity of the BCR-ABL fusion protein. In this study, we generated induced pluripotent stem cells (iPSCs) with a normal karyotype, using cells from a patient with CML and a Philadelphia chromosome. These human iPSCs showed positive pluripotency markers and differentiated into three germ layers. This iPSC line can be useful for the study of CML, namely the biology of hematopoietic stem cells with normal karyotype in CML, and for the development of patient-specific immunological treatment.

Original languageEnglish
Article number102465
JournalStem Cell Research
Volume55
DOIs
Publication statusPublished - 2021 Aug

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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