Generation of large pore channels for bone tissue engineering using camphene-based freeze casting

Byung Ho Yoon, Young-Hag Koh, Chee Sung Park, Hyoun Ee Kim

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

The present study reports an innovative way to produce large pore channels with a size >100 μm for applications in bone tissue engineering using the camphene-based freeze casting method, and using an unusually high freezing temperature, which is close to the solidification temperature of the slurry, in order to allow the formation of excessively overgrown camphene dendrites due to the extremely low solidification velocity. To accomplish this, hydroxyapatite (HA)/slurries with various solid loadings (10, 15, and 20 vol%) were frozen at 35°C for 20 h. The frozen samples were freeze dried and sintered at 1250°C for 3 h. All of the fabricated samples showed highly porous structures with large pore channels >100 μm in size and dense HA walls without any noticeable defects, such as cracks or pores. As the initial solid loading was increased from 10 to 20 vol%, the porosity of the sample decreased linearly from 76% to 55%, while the pore channels became narrower. However, the compressive strength was remarkably improved from 2.5 to 16.7 MPa.

Original languageEnglish
Pages (from-to)1744-1752
Number of pages9
JournalJournal of the American Ceramic Society
Volume90
Issue number6
DOIs
Publication statusPublished - 2007 Jun 1
Externally publishedYes

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Camphene
Durapatite
Hydroxyapatite
Tissue engineering
Solidification
bone
Bone
Casting
solidification
engineering
Dendrites (metallography)
Slurries
Freezing
Compressive strength
Porosity
Cracks
compressive strength
Temperature
Defects
slurry

ASJC Scopus subject areas

  • Ceramics and Composites

Cite this

Generation of large pore channels for bone tissue engineering using camphene-based freeze casting. / Yoon, Byung Ho; Koh, Young-Hag; Park, Chee Sung; Kim, Hyoun Ee.

In: Journal of the American Ceramic Society, Vol. 90, No. 6, 01.06.2007, p. 1744-1752.

Research output: Contribution to journalArticle

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