Generation of normal induced pluripotent stem cell line KUMCi002-A from bone marrow CD34+ cells of patient with multiple myeloma disease having 13q deletion and IGH translocation

Seung Jin Lee, Ji Hea Kim, Ka Won Kang, Byung Hyun Lee, Byung Soo Kim

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Multiple myeloma (MM) is a hematological cancer characterized by an uncontrolled proliferation of antibody-secreting plasma cells within the bone marrow. Currently, cell therapy such as chimeric antigen receptor T-cell (CAR-T) based on induced pluripotent stem cells (iPSCs) has received attention for treating MM. However, the generation of iPSCs from MM patients appears to be very rarely reported. Here we generated an iPSC line from CD34+ bone marrow cells of a patient with MM using human placenta-derived cell conditioned medium (hPCCM), offering a relatively high efficiency in humanized conditions. This iPSC line might be a useful model for research on MM.

Original languageEnglish
Article number102030
JournalStem Cell Research
Volume49
DOIs
Publication statusPublished - 2020 Dec

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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