Generation of the induced pluripotent stem cell line KUMi001-A carrying the Philadelphia chromosome from a chronic myeloid leukemia patient

Ji Hea Kim, Ka Won Kang, Byung Hyun Lee, Young Park, Byung Soo Kim

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic myeloid leukemia (CML) is caused by the BCR-ABL fusion protein, which dysregulates tyrosine kinase activity. In this study, we generated induced pluripotent stem cells (iPSCs) carrying the Philadelphia chromosome from a CML patient with the BCR-ABL fusion protein. CML iPSCs were positive for pluripotency markers and had the ability to differentiate into the three germ layers. This iPSC cell line could be useful for studying CML pathogenesis as well as for drug development to treat CML.

Original languageEnglish
Article number102464
JournalStem Cell Research
Volume55
DOIs
Publication statusPublished - 2021 Aug

Keywords

  • Chronic myeloid leukemia
  • Induced pluripotent stem cells
  • Philadelphia chromosome

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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