Genes involved in neurodevelopment, neuroplasticity and major depression: No association for CACNA1C, CHRNA7 and MAPK1

Marco Calabrò, Laura Mandelli, Concetta Crisafulli, Soo Jung Lee, Tae Youn Jun, Sheng Min Wang, Ashwin A. Patkar, Prakash S. Masand, Changsu Han, Chi Un Pae, Alessandro Serretti

    Research output: Contribution to journalArticlepeer-review

    12 Citations (Scopus)


    Objective: Genetics factors are likely to play a role in the risk, clinical presentation and treatment outcome in major depressive disorder (MDD). In this study, we investigated the role of three candidate genes for MDD; calcium voltagegated channel subunit alpha1 C (CACNA1C ), cholinergic receptor nicotinic alpha 7 subunit (CHRNA7 ), and mitogenactivated protein kinase 1 (MAPK1 ). Methods: Two-hundred forty-two MDD patients and 326 healthy controls of Korean ancestry served as samples for the analyses. Thirty-nine single nucleotide polymorphisms (SNPs) within CACNA1C, CHRNA7, and MAPK1 genes were genotyped and subsequently tested for association with MDD (primary analysis) and other clinical features (symptoms' severity, age of onset, history of suicide attempt, treatment outcome) (secondary analyses). Single SNPs, haplotypes and epistatic analyses were performed. Results: Single SNPs were not associated with disease risk and clinical features. However, a combination of alleles (haplotype) within MAPK1 was found associated with MDD-status. Secondary analyses detected a possible involvement of CACNA1C haplotype in resistance to antidepressant treatment. Conclusion: These data suggest a role for MAPK1 and CACNA1C in MDD risk and treatment resistance, respectively. However, since many limitations characterize the analysis, the results must be considered with great caution and verified.

    Original languageEnglish
    Pages (from-to)364-368
    Number of pages5
    JournalClinical Psychopharmacology and Neuroscience
    Issue number3
    Publication statusPublished - 2019


    • CACNA1C
    • CHRNA7
    • Deep phenotyping
    • MAPK1
    • Major depressive disorder

    ASJC Scopus subject areas

    • Psychiatry and Mental health
    • Behavioral Neuroscience
    • Pharmacology (medical)


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